As3+ or/and Cu2+ exposure triggers oxidative stress imbalance, induces inflammatory response and apoptosis in chicken brain

Arsenic (As) and copper (Cu) are common environmental pollutants in nature. When they are excessively present in living organisms, they can cause heavy metal poisoning. There were relatively few studies of the toxicological concentrations of As and Cu in the brain using chicken as a model. Therefore...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2020-10, Vol.203, p.110993-110993, Article 110993
Main Authors: Nie, Xiaopan, Wang, Yu, Zhao, Hongjing, Guo, Menghao, Liu, Yachen, Xing, Mingwei
Format: Article
Language:English
Subjects:
Apoptosis
Arsenic
Copper
Inflammation
Neurotoxicity
Oxidative stress
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Summary:Arsenic (As) and copper (Cu) are common environmental pollutants in nature. When they are excessively present in living organisms, they can cause heavy metal poisoning. There were relatively few studies of the toxicological concentrations of As and Cu in the brain using chicken as a model. Therefore, in this study, arsenic trioxide or/and copper sulfate were added to chicken diets for a 12-week toxicity test. The test results showed that excessive intake of As or/and Cu led to a significant reduction in the total antioxidant capacity (T-AOC), catalase (CAT) and hydroxyl radicals. And significant increase in nitric oxide synthase (NOS) indicates an imbalanced oxidation reaction. In addition, the increase in heat shock protein (HSPs), the increase of NF-κB pathway-related pro-inflammatory mediators, the change of apoptosis factors on the death receptor and mitochondrial apoptosis pathway show that, As or/and Cu exposure induced chicken brain has heat shock response (HSP), tissue inflammation and apoptosis. This damage is inseparable from the oxidative imbalance. It is worth noting that these injury changes are time-dependent, and the combined effect of these two metals is more severe than that of a single group of injuries. Our findings can inform the regulation of animal feed additives and avoid agricultural economic losses or biological health damage. [Display omitted] •Arsenic trioxide or/and copper sulfate can induce brain damage in chicken model.•Copper sulfate exacerbates the neurotoxicity of arsenic trioxide.•Oxidative stress may mediate inflammation and apoptosis in chicken brain tissue.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2020.110993