Longitudinal changes in plasma sex hormone concentrations correlate with changes in CT‐measured regional adiposity among Japanese American men over 10 years

Objective Ageing in male adults is typically accompanied by adiposity accumulation and changes in circulating sex hormone concentrations. We hypothesized that an ageing‐associated increase in oestrogens and decrease in androgens would correlate with an increase in adiposity. Design 10‐year prospecti...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2020-11, Vol.93 (5), p.555-563
Main Authors: Dinh, Kathryn T., Amory, John K., Matsumoto, Alvin M., Marck, Brett T., Fujimoto, Wilfred Y., Leonetti, Donna L., Boyko, Edward J., Page, Stephanie T., Rubinow, Katya B.
Format: Article
Language:English
Subjects:
Adipose tissue
Aging
Androgens
Body weight
Diabetes mellitus
Dihydrotestosterone
Estrogens
Estrone
intra‐abdominal fat
Japanese American
Japanese Americans
Liquid chromatography
Mass spectroscopy
Multivariate analysis
oestradiol
oestrone
Overweight
Plasma
Sex hormones
subcutaneous fat
Testosterone
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Summary:Objective Ageing in male adults is typically accompanied by adiposity accumulation and changes in circulating sex hormone concentrations. We hypothesized that an ageing‐associated increase in oestrogens and decrease in androgens would correlate with an increase in adiposity. Design 10‐year prospective, observational study. Study subjects A total of 190, community‐dwelling men in the Japanese American Community Diabetes Study. Measurements At 0 and 10 years, CT scanning quantified intra‐abdominal fat (IAF) and subcutaneous fat (SCF) areas while plasma concentrations of oestradiol, oestrone, testosterone and dihydrotestosterone were measured by liquid chromatography‐tandem‐mass spectrometry at each time point. Multivariate linear regression analyses assessed correlations between 10‐year changes in hormone concentrations and IAF or SCF, adjusting for age and baseline fat depot area. Results Participants were middle‐aged [median 54.8 years, interquartile range (IQR) 39.9‐62.8] men and mostly overweight by Asian criterion (median BMI 24.9, IQR 23.3‐27.1) and with few exceptions had normal sex‐steroid concentrations. Median oestradiol and dihydrotestosterone did not change significantly between 0 and 10 years (P = .084 and P = .596, respectively) while median oestrone increased (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14278