Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study

Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were ass...

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Bibliographic Details
Published in:Heart and vessels 2021, Vol.36 (1), p.14-23
Main Authors: Funck, Kristian L., Budde, Ricardo P. J., Viuff, Mette H., Wen, Jan, Jensen, Jesper M., Nørgaard, Bjarne L., Bons, Lidia R., Duijnhouwer, Anthonie L., Dey, Damini, Mortensen, Kristian H., Andersen, Niels H., Roos-Hesselink, Jolien W., Gravholt, Claus H.
Format: Article
Language:English
Subjects:
Angiography
Arteriosclerosis
Atherosclerosis
Biomedical Engineering and Bioengineering
Blood pressure
Cardiac Surgery
Cardiology
Cardiovascular disease
Cardiovascular diseases
Comparative analysis
Computed tomography
Coronary artery
Coronary artery disease
Defects
Diabetes mellitus (non-insulin dependent)
Genetic disorders
Health risks
Heart diseases
Karyotypes
Medical imaging
Medicine
Medicine & Public Health
NCT
NCT01678261
Original Article
Risk analysis
Risk factors
Turner's syndrome
Vascular Surgery
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Summary:Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were assessed for the presence and volume of subclinical CAD using coronary CT angiography. Karyotype, the presence of congenital heart defects and conventional cardiovascular risk factors were also registered. Comparative analyses were performed (1) between women with and without TS and (2) in the TS group, between women with and without subclinical CAD. The prevalence of CAD, in crude and adjusted analyses, was not increased for women with TS (crude prevalence: 40 [35%] in TS vs. 25 [47%] in controls, p  = 0.12). The volume of atherosclerosis was not higher in women with TS compared with controls (median and interquartile range 0 [0–92] in TS vs. 0 [0–81]mm 3 in controls, p  = 0.29). Among women with TS, women with subclinical CAD were older (46 ± 13 vs. 37 ± 11 years, p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-020-01660-7