Risk and impact of invasive fungal infections in patients with multiple myeloma

Infection is associated with great morbidity and mortality in patients with multiple myeloma (MM), but evidence for invasive fungal infections (IFIs) is lacking. We aimed to investigate risk factors for IFI in MM patients and to determine its impact on patients’ survival. We retrospectively analyzed...

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Bibliographic Details
Published in:Annals of hematology 2020-08, Vol.99 (8), p.1813-1822
Main Authors: Tsai, Chun-Kuang, Liu, Yao-Chung, Kuan, Ai Seon, Lee, Kang-Lung, Yeh, Chiu-Mei, Lee, Yu-Ting, Hsiao, Liang-Tsai, Ko, Po-Shen, Wang, Hao-Yuan, Chen, Po-Min, Liu, Jin-Hwang, Hong, Ying-Chung, Liu, Chia-Jen, Gau, Jyh-Pyng
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Allografts
Female
Fungal infections
Health risk assessment
Hematology
Humans
Invasive Fungal Infections - blood
Invasive Fungal Infections - epidemiology
Invasive Fungal Infections - etiology
Invasive Fungal Infections - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Multiple myeloma
Multiple Myeloma - blood
Multiple Myeloma - epidemiology
Multiple Myeloma - therapy
Oncology
Original Article
Risk Factors
Stem Cell Transplantation
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Summary:Infection is associated with great morbidity and mortality in patients with multiple myeloma (MM), but evidence for invasive fungal infections (IFIs) is lacking. We aimed to investigate risk factors for IFI in MM patients and to determine its impact on patients’ survival. We retrospectively analyzed MM patients at Taipei Veterans General Hospital in Taiwan between January 2002 and October 2018. MM was diagnosed according to the International Myeloma Working Group criteria. IFI was defined according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. All risk factors of IFI in MM patients were estimated using Cox regression models in the univariate and multivariate analyses. Of the 623 patients recruited, 22 (3.5%) were diagnosed with proven or probable IFI. Light chain disease (adjusted hazard ratio [HR] 6.74, 95% confidence interval [CI] 2.10–21.66), hemoglobin less than 8 g/dl (adjusted HR 3.34, 95% CI 1.32–8.42), serum albumin
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-020-04125-z