Development of disturbance of consciousness is associated with increased severity in acute pancreatitis

Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP. From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collec...

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Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020-07, Vol.20 (5), p.806-812
Main Authors: Hágendorn, Roland, Vincze, Áron, Izbéki, Ferenc, Gajdán, László, Gódi, Szilárd, Illés, Anita, Sarlós, Patrícia, Farkas, Nelli, Erőss, Bálint, Lillik, Veronika, Illés, Dóra, Varjú, Péter, Márta, Katalin, Török, Imola, Papp, Mária, Vitális, Zsuzsanna, Bod, Barnabás, Hamvas, József, Szepes, Zoltán, Takács, Tamás, Czakó, László, Márton, Zsolt, Szentesi, Andrea, Párniczky, Andrea, Hegyi, Péter, Mikó, Alexandra
Format: Article
Language:English
Subjects:
Acute pancreatitis
Age
Alcohol
Alcohol withdrawal
Consciousness
Delirium
Disturbance of consciousness
Etiology
Hospitalization
Mortality
Older people
Pancreas
Pancreatitis
Statistical analysis
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Summary:Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient’s condition, but we have no exact data on how DOC affects the outcome of AP. From the Hungarian Pancreatic Study Groups’ AP registry, 1220 prospectively collected cases were analyzed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p 
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2020.05.009