The role of sleep disturbances in depressive-like behavior with emphasis on α-ketoglutarate dehydrogenase activity in rats

•Immobility was increased following 48 h partial sleep deprivation (PSD48).•Swimming was increased following 48 h total sleep deprivation (TSD48).•Climbing was decreased following TSD48/PSD48.•Napping restored some effects of TSD48/PSD48 on immobility, swimming and climbing.•α-KGDH activity was incr...

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Published in:Physiology & behavior 2020-10, Vol.224, p.113023-113023, Article 113023
Main Authors: Kordestani-Moghadam, Parastou, Nasehi, Mohammad, Vaseghi, Salar, Khodagholi, Fariba, Zarrindast, Mohammad-Reza
Format: Article
Language:English
Subjects:
Depressive-like behavior
Forced Swim Test (FST)
Napping
Sleep deprivation (SD)
α-ketoglutarate dehydrogenase (α-KGDH)
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Summary:•Immobility was increased following 48 h partial sleep deprivation (PSD48).•Swimming was increased following 48 h total sleep deprivation (TSD48).•Climbing was decreased following TSD48/PSD48.•Napping restored some effects of TSD48/PSD48 on immobility, swimming and climbing.•α-KGDH activity was increased in left amygdala following TSD48/PSD48. Sleep disorders may induce anxiety- and depressive-like behaviors. Furthermore, sleep disorders can alter the function of α-KGDH (α-ketoglutarate dehydrogenase), which is involved in the citric acid cycle. In this study, we evaluated the effect of two models of sleep deprivation (SD) including total SD (TSD) and partial SD (PSD), and two models of napping combined with each models of SD on rats’ performance in Forced Swim Test (FST) and α-KGDH activity in both hemispheres of the amygdala. 64 male Wistar rats were used in this study. A modified water box was also used to induce SD. The results showed that, immobility was increased in 48-hour PSD group, indicating a possible depressive-like behavior. Swimming time was also increased following 48-hour TSD. However, climbing time was decreased in 48-hour PSD/TSD groups. Additionally, α-KGDH activity was increased in the left amygdala in 48-hour TSD and PSD groups. In conclusion, PSD may increase depressive-like behavior. TSD and PSD can decrease swimming time but increase climbing time, and these effects may be related to serotonergic and noradrenergic transmissions, respectively. Increase in α-KGDH activity in the left amygdala may be related to the brain's need for more energy during prolonged wakefulness. α-KGDH activity in the right amygdala was unaffected probably due to a decrease in alertness following SD.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2020.113023