Time trends in the incidence and survival of vaginal squamous cell carcinoma and high-grade vaginal intraepithelial neoplasia in Denmark – A nationwide population-based study

To describe trends in incidence of high-grade vaginal intraepithelial neoplasia (VaIN) and vaginal squamous cell carcinoma (SCC) in Denmark. For vaginal SCC, we also examine 5-year relative survival and mortality. All high-grade VaIN cases diagnosed 1997–2017 and vaginal SCCs during 1978–2017 were i...

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Bibliographic Details
Published in:Gynecologic oncology 2020-09, Vol.158 (3), p.734-739
Main Authors: Bertoli, Hanna Kristina, Baandrup, Louise, Aalborg, Gitte Lerche, Kjaer, Alexander K., Thomsen, Louise T., Kjaer, Susanne K.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma in Situ - epidemiology
Carcinoma in Situ - mortality
Carcinoma in Situ - pathology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Denmark - epidemiology
Female
Humans
Incidence
Middle Aged
Mortality - trends
Neoplasm Grading
Neoplasm Staging
Relative survival
Vaginal cancer
Vaginal Neoplasms - epidemiology
Vaginal Neoplasms - mortality
Vaginal Neoplasms - pathology
VaIN
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Summary:To describe trends in incidence of high-grade vaginal intraepithelial neoplasia (VaIN) and vaginal squamous cell carcinoma (SCC) in Denmark. For vaginal SCC, we also examine 5-year relative survival and mortality. All high-grade VaIN cases diagnosed 1997–2017 and vaginal SCCs during 1978–2017 were identified in two high-quality nationwide registers. Age-standardized incidence rates and average annual percentage change (AAPC) were assessed. For vaginal SCC, 5-year relative survival was calculated, and Cox regression was applied to study the effect of selected characteristics on mortality. Altogether, 831 cases of high-grade VaIN and 721 vaginal SCCs were identified. The age-standardized incidence rate of high-grade VaIN showed no clear trend over time. However, when we stratified by age and divided the study period according to HPV vaccine licensure in Denmark (2006), the incidence of high-grade VaIN decreased significantly by 15.6% per year (95% CI: −23.2, −7.3%) after 2007 onwards among the youngest women (
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2020.05.683