Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma

Background The concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. Patients and Methods A tota...

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Bibliographic Details
Published in:Annals of surgical oncology 2021, Vol.28 (1), p.439-446
Main Authors: Yamada, Shinichiro, Shimada, Mitsuo, Morine, Yuji, Imura, Satoru, Ikemoto, Tetsuya, Arakawa, Yusuke, Saito, Yu, Yoshikawa, Masato, Miyazaki, Katsuki
Format: Article
Language:English
Subjects:
Aged
Aging
Carcinoma, Hepatocellular - surgery
Frail Elderly
Frailty
Geriatrics
Hepatectomy
Hepatobiliary Tumors
Hepatocellular carcinoma
Humans
Liver cancer
Liver Neoplasms - surgery
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Neoplasm Recurrence, Local
Oncology
Patients
Prognosis
Surgery
Surgical Oncology
Survival
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Summary:Background The concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. Patients and Methods A total of 92 patients over 75 years old who underwent hepatectomy were enrolled in this study. Frailty was defined as clinical frailty scale (CFS) ≥ 4. Patients were divided into two groups, i.e., frailty group ( n  = 21) and no-frailty group ( n  = 71), and clinicopathological features were compared between them. Results The frailty group showed significant higher PIVKA-II level and larger tumor diameter ( p 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08742-w