Association between the high risk for obstructive sleep apnea and intracranial carotid artery calcification in patients with acute ischemic stroke

Purpose Obstructive sleep apnea (OSA) is an independent risk factor for stroke. Furthermore, intracranial carotid artery calcification (ICAC) is a marker for subclinical atherosclerosis and future cardiovascular events. We investigated the association between the high risk for OSA and ICAC in patien...

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Bibliographic Details
Published in:Sleep & breathing 2021-03, Vol.25 (1), p.299-307
Main Authors: Woo, Ho Geol, Song, Tae-Jin, Jung, Jo Sung, Oh, Se Won, Lee, Seung Cheol, Seok, Jin Myoung, Yang, Kwang Ik
Format: Article
Language:English
Subjects:
Apnea
Arteriosclerosis
Atherosclerosis
Calcification
Calcification (ectopic)
Calcium
Carotid arteries
Carotid artery
Dentistry
Diabetes mellitus
Internal Medicine
Ischemia
Medicine
Medicine & Public Health
Neurology
Otorhinolaryngology
Pediatrics
Pneumology/Respiratory System
Risk factors
Risk groups
Sleep
Sleep apnea
Sleep Breathing Physiology and Disorders • Original Article
Sleep disorders
Stroke
Veins & arteries
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Summary:Purpose Obstructive sleep apnea (OSA) is an independent risk factor for stroke. Furthermore, intracranial carotid artery calcification (ICAC) is a marker for subclinical atherosclerosis and future cardiovascular events. We investigated the association between the high risk for OSA and ICAC in patients with acute ischemic stroke. Methods We retrospectively investigated 73 patients who were admitted to the hospital with acute ischemic stroke in the internal carotid artery (ICA) territory due to large-artery atherosclerosis. The risk for OSA was assessed using the Berlin Questionnaire, and patients were classified into low-risk (LR-OSA) and high-risk groups (HR-OSA). We compared the burden of ICAC between the two groups. Univariable and multivariable analyses were conducted to investigate the association of high risk for OSA with the presence of calcium in intracranial ICA. Results The HR-OSA group of 35 patients (48%) was significantly older and had a higher rate of hypertension and diabetes mellitus than the LR-OSA group. The HR-OSA group had more frequent ICAC (92% vs. 63%, p  
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-020-02117-x