New dibenzocyclooctadiene lignan from stems of Kadsura heteroclita

Kadsura heteroclita Roxb. Craib. (Schisandraceae), is a vine plant mainly distributed in southwest part of China. A new dibenzocyclooctadiene lignan, kadsulignan W (1), along with eleven known lignans (2-12) were isolated from chloroform soluble fraction of stems of Kadsura heteroclita. The structur...

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Bibliographic Details
Published in:Natural product research 2022-01, Vol.36 (1), p.8-17
Main Authors: Shehla, Nuzhat, Li, Bin, Zhao, Jianping, Cao, Liang, Jian, Yuqing, Khan, Ikhlas A., Liao, Duan-fang, Rahman, Atta-ur, Choudhary, M. Iqbal, Wang, Wei
Format: Article
Language:English
Subjects:
antioxidative
Cyclooctanes
cytotoxicity
dibenzocyclooctadiene lignan
Humans
Kadsura
Kadsura heteroclita
Lignans
Molecular Structure
Plant Stems
Schisandraceae
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Summary:Kadsura heteroclita Roxb. Craib. (Schisandraceae), is a vine plant mainly distributed in southwest part of China. A new dibenzocyclooctadiene lignan, kadsulignan W (1), along with eleven known lignans (2-12) were isolated from chloroform soluble fraction of stems of Kadsura heteroclita. The structure of new lignan was elucidated by extensive spectroscopic techniques, namely one- and two-dimensional NMR spectroscopy, and HRESI-MS analysis. The absolute configuration of the biphenyl ring in the new dibenzocyclooctadiene lignan was discerned by circular dichroism (CD) spectroscopy. Antioxidative effects of these compounds were evaluated on human isolated neutrophils, and compounds 5, 8, 9, and 10 were found to be strongly active with the IC 50 of 36.68, 34.41, 35.97, and 33.65 µM, respectively. Furthermore, compound 8 was also found to be cytotoxic against human gastric cancer cells (BGC 823), and human cervical cancer cell lines (HeLa) with the IC50 values of 11.0, and 23.8 µM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1758378