The role of spread through air spaces (STAS) in lung adenocarcinoma prognosis and therapeutic decision making
•STAS is a new invasion pattern in lung ADC classification that can potentially be identified pre- and intra-operatively.•STAS has been described in other histologic subtypes, including squamous cell carcinoma and neuroendocrine tumors.•STAS is associated to EGFR WT, BRAF mutations and ROS1/ALK rear...
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| Published in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2020-08, Vol.146, p.127-133 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | •STAS is a new invasion pattern in lung ADC classification that can potentially be identified pre- and intra-operatively.•STAS has been described in other histologic subtypes, including squamous cell carcinoma and neuroendocrine tumors.•STAS is associated to EGFR WT, BRAF mutations and ROS1/ALK rearrangements.•STAS is a negative prognostic marker of recurrence and survival.•STAS in sublobar resection is associated to locoregional recurrence.
Spread through air spaces (STAS) was included as a novel pattern of invasion in lung adenocarcinoma by the World Health Organization in 2015. Since then, multiple studies have investigated the association of STAS with clinicopathological and molecular features and its implication in the prognosis of early stage lung cancer patients undergoing different surgery types. The aim of this comprehensive review is to present current data on the role of STAS and its perspective in lung adenocarcinoma management. |
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| ISSN: | 0169-5002 1872-8332 |