Relationships between Early Nutrition, Illness, and Later Outcomes among Infants Born Preterm with Hyperglycemia

To evaluate the effects of hyperglycemia on body composition and neurodevelopment, and how early nutrition and illness modify these relationships in infants born preterm. Prospective data were collected from infants born 150 mg/dL) and nutrient intake. Body composition was measured at discharge and...

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Bibliographic Details
Published in:The Journal of pediatrics 2020-08, Vol.223, p.29-33.e2
Main Authors: Gonzalez Villamizar, Juan David, Haapala, Jacob L., Scheurer, Johannah M., Rao, Raghavendra, Ramel, Sara E.
Format: Article
Language:English
Subjects:
body composition
infant
neurodevelopment
prematurity
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Summary:To evaluate the effects of hyperglycemia on body composition and neurodevelopment, and how early nutrition and illness modify these relationships in infants born preterm. Prospective data were collected from infants born 150 mg/dL) and nutrient intake. Body composition was measured at discharge and 4 months' postmenstrual age (PMA). Bayley Scales of Infant Development III (BSID-III) were administered at 12 months' PMA. Linear regression analysis was performed, adjusting for birth gestational age. Associations between hyperglycemia, body composition, and BSID-III were analyzed in models accounting for first-week nutrition and early illness severity via Score for Neonatal Acute Physiology-II. Mean birth gestational age was 27.8 (SD 2.4) weeks. Hyperglycemia occurred in 48.5% of infants. Hyperglycemia for ≥5 days was negatively associated with fat mass and fat free mass z scores at discharge, and fat free mass z score at 4 months' PMA (P 
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2020.04.038