Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation

Inflammation has been suggested to play a key role in the pathogenesis of atrial fibrillation (AF). Our hypothesis was that this inflammation, mediated by intermediate monocytes and toll-like receptor 4 (TLR4), causes the formation and expansion of low-voltage zones (LVZs). Prior to ablation, the mo...

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Bibliographic Details
Published in:Heart and vessels 2020-12, Vol.35 (12), p.1717-1726
Main Authors: Suehiro, Hideya, Fukuzawa, Koji, Yoshida, Naofumi, Kiuchi, Kunihiko, Takami, Mitsuru, Akita, Tomomi, Tabata, Tokiko, Takemoto, Makoto, Sakai, Jun, Nakamura, Toshihiro, Yatomi, Atsusuke, Takahara, Hiroyuki, Sonoda, Yusuke, Nakasone, Kazutake, Yamamoto, Kyoko, Suzuki, Atsushi, Yamashita, Tomoya, Hirata, Ken-ichi
Format: Article
Language:English
Subjects:
Ablation
Action Potentials
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - diagnosis
Atrial Fibrillation - physiopathology
Biomarkers - blood
Biomedical Engineering and Bioengineering
Cardiac arrhythmia
Cardiac Surgery
Cardiology
CD14 antigen
CD16 antigen
Correlation analysis
Electric potential
Female
Fibrillation
Flow cytometry
GPI-Linked Proteins - blood
Heart Rate
Humans
Inflammation - blood
Inflammation - diagnosis
Inflammation Mediators - blood
Lipopolysaccharide Receptors - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Monocytes
Monocytes - metabolism
Original Article
Pathogenesis
Prospective Studies
Receptors
Receptors, IgG - blood
TLR4 protein
Toll-Like Receptor 4 - blood
Toll-like receptors
Vascular Surgery
Voltage
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Summary:Inflammation has been suggested to play a key role in the pathogenesis of atrial fibrillation (AF). Our hypothesis was that this inflammation, mediated by intermediate monocytes and toll-like receptor 4 (TLR4), causes the formation and expansion of low-voltage zones (LVZs). Prior to ablation, the monocyte subsets of 78 AF patients and TLR4 expression of 66 AF patients were analyzed via a flow cytometric analysis. Based on the CD14/CD16 expression, the monocytes were divided into three subsets: classical, intermediate, and non-classical. At the beginning of the ablation session, voltage mapping was performed. LVZs were defined as all bipolar electrogram amplitudes of 
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-020-01647-4