Assessing the effects of body weight on subchondral bone formation with quantitative 18F-sodium fluoride PET

Objectives The aim of this study was to quantify subchondral bone remodeling in the elbows, hands, knees, and feet using volumetric and metabolic parameters derived from 18 F-sodium fluoride positron emission tomography (NaF-PET) and to assess the convergent validity of these parameters as an index...

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Bibliographic Details
Published in:Annals of nuclear medicine 2020-08, Vol.34 (8), p.559-564
Main Authors: Khaw, Tiffany H., Raynor, William Y., Borja, Austin J., Al-Zaghal, Abdullah, Jonnakuti, Venkata S., Cheng, Nina, Houshmand, Sina, Werner, Thomas J., Alavi, Abass
Format: Article
Language:English
Subjects:
Adaptive algorithms
Arthritis
Biomechanics
Biomedical materials
Body weight
Bone diseases
Bone growth
Bone remodeling
Bone turnover
Computed tomography
Correlation analysis
Degeneration
Emission analysis
Feet
Fluorides
Fluorine isotopes
Hand (anatomy)
Imaging
Joints (anatomy)
Knee
Mathematical analysis
Mechanical loading
Mechanical properties
Medicine
Medicine & Public Health
Metabolism
Metastases
Nuclear Medicine
Original Article
Osteoarthritis
Osteogenesis
Parameters
Positron emission
Positron emission tomography
Radiology
Reliability analysis
Sodium fluoride
Subchondral bone
Tomography
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Summary:Objectives The aim of this study was to quantify subchondral bone remodeling in the elbows, hands, knees, and feet using volumetric and metabolic parameters derived from 18 F-sodium fluoride positron emission tomography (NaF-PET) and to assess the convergent validity of these parameters as an index of joint degeneration and preclinical osteoarthritis. Methods A retrospective analysis was conducted in 34 subjects (32 males, 2 females) with metastatic bone disease who underwent full-body NaF-PET/CT scans. An adaptive contrast-oriented thresholding algorithm was applied to segment NaF-avid regions in the bilateral elbows, hands, knees, and feet of each subject, and metabolically active volume (MAV), maximum standardized uptake value (SUVmax), mean metabolic volumetric product (MVPmean), and partial volume-corrected MVPmean (cMVPmean) of the segmented regions were calculated. Global parameters for MAV, SUVmax, MVPmean, and cMVPmean were defined as the sum of the corresponding values in all the joints of a subject. Inter-rater reliability was determined with Lin’s concordance correlation, and associations of global values with subject body weight and age were assessed with Pearson correlation and Spearman correlation analyses. Results Inter-rater reliability was observed to be the highest in SUVmax ( ρc  = 0.99), followed by MVPmean ( ρc  = 0.96), cMVPmean ( ρc  = 0.93), and MAV ( ρc  = 0.93). MAV, MVPmean, and cMVPmean were observed to significantly increase with weight (all p  
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-020-01482-7