Shortening of the leucocytes’ telomeres length in T2DM independent of age and telomerase activity

Aims This study aimed to examine the role of plasma telomerase (TE), plasma insulin, patient’s age and disease duration in determination of the leucocytes’ telomeres length (LTL) in T2DM. Methods Blood samples from Kuwaiti patients with T2DM (110) and non-diabetic subjects (94) were analyzed by SYBR...

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Bibliographic Details
Published in:Acta diabetologica 2020-11, Vol.57 (11), p.1287-1295
Main Authors: AlDehaini, Dhuha M. B., Al-Bustan, Suzanne A., Ali, Muhalab E., Malalla, Zainab Hasan Abdulla, Sater, Mai, Giha, Hayder A.
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Blood Glucose - metabolism
Body Mass Index
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Female
Humans
Insulin
Insulin Resistance
Internal Medicine
Leukocytes
Leukocytes - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Risk Factors
Telomerase
Telomerase - metabolism
Telomere - metabolism
Telomere Shortening
Telomeres
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Summary:Aims This study aimed to examine the role of plasma telomerase (TE), plasma insulin, patient’s age and disease duration in determination of the leucocytes’ telomeres length (LTL) in T2DM. Methods Blood samples from Kuwaiti patients with T2DM (110) and non-diabetic subjects (94) were analyzed by SYBR Green Quantitative PCR for estimation of the Absolute Human Telomere Length and by ELISA for estimation of the TE activity and insulin level. The body mass index (BMI) and HOMA-IR were calculated. Results The results revealed marked shortening of the LTL in T2DM compared with the non-diabetic subjects (6.068, 2.276–11.652 vs. 10.979, 6.495–23.402 kb), p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-020-01550-4