Cytotoxicity of Potassium Salts of (+)- and (-) Usnic Acid for Paramecium caudatum

We analyzed cytotoxicity of water-soluble potassium salts of (+)- and (-) usnic acid (UA) for ciliates P. caudatum . The median lethal concentrations for (+)- and (-) enantiomers did not significantly differ and were 7.5±0.5 and 6.7±0.4, respectively. In a concentration of 8 μM, (+)-UA and (-)-UA sa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-05, Vol.169 (1), p.110-113
Main Authors: Prokop’ev, I. A., Kan, M. U.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Ciliates
Cytotoxicity
Enantiomers
Food vacuoles
Internal Medicine
Laboratory Medicine
Oxidative stress
Pathology
Phagocytosis
Potassium
Salts
Usnic acid
Vacuoles
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Summary:We analyzed cytotoxicity of water-soluble potassium salts of (+)- and (-) usnic acid (UA) for ciliates P. caudatum . The median lethal concentrations for (+)- and (-) enantiomers did not significantly differ and were 7.5±0.5 and 6.7±0.4, respectively. In a concentration of 8 μM, (+)-UA and (-)-UA salts increased the content of TBA-reactive products, which indicates the formation of oxidative stress under the action of high UA concentrations. In the presence of (+)-UA and (-)-UA salts in a concentration range from 2 to 8 μM, the number of food vacuoles in ciliates decreased, which attested to a decrease in phagocytosis activity. The concentrations of UA enantiomers >0.5 μM affected macronucleus morphology (shape and size). The cytotoxic activity of (+)-UA and (-)-UA salts against P. caudatum did not differ.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04835-4