Proteomics Reveals Plasma Biomarkers for Ischemic Stroke Related to the Coagulation Cascade

Stroke has a high incidence rate and often leads to permanent disability, particularly if it is not treated promptly. However, no blood biomarkers for early diagnosis are available to date. Therefore, we sought to detect stroke-specific blood biomarkers by identifying proteins associated with the un...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2020-09, Vol.70 (9), p.1321-1331
Main Authors: Lee, Jiyeong, Mun, Sora, Park, Arum, Kim, Doojin, Lee, Yoo-Jin, Kim, Hyo-Jin, Choi, Hyebin, Shin, Miji, Lee, Soo Joo, Kim, Jae Guk, Chun, Yeon Tae, Kang, Hee-Gyoo
Format: Article
Language:English
Subjects:
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood coagulation
Cell Biology
Coagulation
Diagnostic systems
Fibrinogen
Glycoproteins
Histidine
Ischemia
Liquid chromatography
Mass spectra
Mass spectrometry
Mass spectroscopy
Neurochemistry
Neurology
Neurosciences
Proteins
Proteomics
Prothrombin
Stroke
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Summary:Stroke has a high incidence rate and often leads to permanent disability, particularly if it is not treated promptly. However, no blood biomarkers for early diagnosis are available to date. Therefore, we sought to detect stroke-specific blood biomarkers by identifying proteins associated with the underlying coagulation mechanism, which accounts for more than 80% of all stroke cases. Protein profiling was performed using blood samples from 16 healthy controls and 18 patients who suffered a stroke as the discovery set. We identified upregulated proteins (> 1.5-fold change and p value
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-020-01545-4