Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

•In most of parental ages strata no association with leukaemia risk was found.•A positive association between risk of childhood ALL was observed with younger parental ages.•A positive association between risk of childhood AML was observed with younger parental ages. The parental age at conception ha...

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Published in:Cancer epidemiology 2020-08, Vol.67, p.101731-101731, Article 101731
Main Authors: Jiménez-Hernández, Elva, Duarte-Rodríguez, David Aldebarán, Núñez-Enriquez, Juan Carlos, Flores-Lujano, Janet, Martín-Trejo, Jorge Alfonso, Espinoza-Hernández, Laura Eugenia, Arellano-Galindo, José, Medina-Sanson, Aurora, García-Jiménez, Xochiketzalli, Paredes-Aguilera, Rogelio, Flores-Villegas, Luz Victoria, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Amador-Sánchez, Raquel, Dosta-Herrera, Juan José, Mondragón-García, Javier Anastacio, Valdés-Guzmán, Heriberto, Mejía-Pérez, Laura, Espinoza-Anrubio, Gilberto, Paz-Bribiesca, María Minerva, Salcedo-Lozada, Perla, Landa-García, Rodolfo Ángel, Ramírez-Colorado, Rosario, Hernández-Mora, Luis, Pérez-Saldivar, María Luisa, Santamaría-Ascencio, Marlene, López-Loyola, Anselmo, Godoy-Esquivel, Arturo Hermilo, García-López, Luis Ramiro, Anguiano-Ávalos, Alison Ireri, Mora-Rico, Karina, Castañeda-Echevarría, Alejandro, Rodríguez-Jiménez, Roberto, Cibrian-Cruz, José Alberto, Cárdenas-Cardos, Rocío, Altamirano-García, Martha Beatriz, Sánchez-Ruiz, Martin, Rivera-Luna, Roberto, Rodríguez-Villalobos, Luis Rodolfo, Hernández-Pérez, Francisco, Olvera-Durán, Jaime Ángel, García-Cortés, Luis Rey, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Bekker-Méndez, Vilma Carolina, Jiménez-Morales, Silvia, Rosas-Vargas, Haydee, Mejía-Aranguré, Juan Manuel
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Acute myeloid leukemia
Adolescent
Adolescents
Adult
Age
Alcohol
Birth order
Cancer
Case-Control Studies
Child
Child, Preschool
Children
Children & youth
Confidence intervals
Control methods
Disease
Down syndrome
Epidemiology
Etiology
Female
Fertilization
Fractures
Hospitals
Humans
Infant
Infant, Newborn
Infections
Interviews
Leukemia
Leukemia, Myeloid, Acute - epidemiology
Male
Maternal Age
Mexico - epidemiology
Odds Ratio
Offspring
Parental age
Parents & parenting
Paternal Age
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Pregnancy
Questionnaires
Regression analysis
Risk analysis
Risk Factors
Smoking
Statistical analysis
Strata
Young Adult
Young adults
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Summary:•In most of parental ages strata no association with leukaemia risk was found.•A positive association between risk of childhood ALL was observed with younger parental ages.•A positive association between risk of childhood AML was observed with younger parental ages. The parental age at conception has been reported to be a risk factor for childhood acute leukaemia (AL); however, the relationship is controversial. The aim of the present study was to investigate the association between parental age at conception and the risk of AL in Mexican children, a population with a high incidence of the disease and a high prevalence of pregnancies in adolescents and young adults. A multicentre case-control study was conducted. Incident AL cases younger than 17 years of age diagnosed between 2010 and 2015 were included. Controls were matched with cases according to age, sex, and health institution. Using logistic regression analysis, adjusted odds ratios (aOR) and 95 % confidence intervals (95 % CI) were calculated for each maternal stratum after adjusting for paternal age at conception of index child. The maternal age between 25 and 29.99 years was selected as the reference category. In most strata where maternal and paternal ages were assessed, no association was found with the risk of developing acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring. An increased risk for AML was observed when the mother was between 20 and 24.99 years of age and the father aged 25−29.99 years (aOR, 1.94; 95 % CI, 1.03–3.67). In addition, there was a positive association for ALL when the mother´s age was between 20 and 24.99 years and the father was
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2020.101731