Obesity, Fat Tissue Parameters, and Arterial Stiffness in Renal Transplant Recipients

Arterial stiffness and altered body composition (increased body fat mass [BFM] and decreased lean body mass) are acknowledged risk factors for adverse outcomes after kidney transplantation related to cardiovascular diseases. The aim of the study was the assessment of the relationship between arteria...

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Bibliographic Details
Published in:Transplantation proceedings 2020-10, Vol.52 (8), p.2341-2346
Main Authors: Heleniak, Zbigniew, Illersperger, Sarah, Brakemeier, Susanne, Dębska-Ślizień, Alicja, Budde, Klemens, Halleck, Fabian
Format: Article
Language:English
Subjects:
Adipose Tissue - physiopathology
Body Composition
Body Mass Index
Cardiovascular Diseases - etiology
Cross-Sectional Studies
Female
Heart Disease Risk Factors
Humans
Intra-Abdominal Fat
Kidney Transplantation - adverse effects
Male
Middle Aged
Obesity - complications
Obesity - physiopathology
Postoperative Complications - etiology
Renal Dialysis - statistics & numerical data
Risk Factors
Vascular Stiffness
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Summary:Arterial stiffness and altered body composition (increased body fat mass [BFM] and decreased lean body mass) are acknowledged risk factors for adverse outcomes after kidney transplantation related to cardiovascular diseases. The aim of the study was the assessment of the relationship between arterial stiffness and fat tissue parameters in renal transplants recipients (RTrs). A group of 344 RTrs with stable disease and a mean age of 52.7 years (62.5% men) who underwent transplantation between 1994 and 2018 were randomly enrolled in the study. The following parameters of arterial stiffness were measured: brachial-ankle and carotid-femoral pulse waves velocities (baPWVs left and right, cfPWVs). The obesity and fat tissue (body mass index [BMI], waist-to-hip ratio [WHR], BFM, fat free mass [FFM], percent body fat [PBF], trunk segmental fat analysis [TSFA], and visceral fat area [VFA]) parameters were assessed with InBody 170. The median time of dialysis and after kidney transplantation was 58.5 and 78 months, respectively. Obesity according BMI, WHR, and VFA was diagnosed in 49.7%, 45.0%, and 44.5% of patients, respectively. The median value of BFM, FFM, VFA, and TSFA and the mean value of PBF were 19.3 kg, 55 kg, 93.2 cm2, 24.9 kg, and 27.3%, respectively. We found significant positive correlations among WHR, VFA, baPWV right, baPWV left, and cfPWV. Obesity and visceral fat tissue influence on arterial stiffness. The analysis of magnitude of obesity and body fat tissue parameters can be used as an additional cardiovascular risk factor in RTrs. •Increased body fat mass is a cardiovascular risk factor.•Visceral fat tissue has an influence on arterial stiffness.•Body mass index correlates with visceral fat tissue.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2020.01.118