Mental status and physical activity in patients with homozygous familial hypercholesterolemia: A subgroup analysis of a nationwide survey (A-HIT1 registry)

Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening disease due to high serum low-density lipoprotein (LDL) cholesterol levels. LDL cholesterol–lowering interventions are fundamental for patients with HoFH. It was aimed to investigate the association between the mental status...

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Published in:Journal of clinical lipidology 2020-05, Vol.14 (3), p.361-370.e2
Main Authors: Kuman Tunçel, Özlem, Kayıkçıoğlu, Meral, Pırıldar, Şebnem, Yılmaz, Mehmet, Kaynar, Leylagül, Aktan, Melih, Durmuş, Rana Berru, Gökçe, Cumali, Temizhan, Ahmet, Özcebe, Osman İlhami, Karaağaç Akyol, Tülay, Okutan, Harika, Sağ, Saim, Öz Gül, Özen, Yenerçağ, Mustafa, Altunkeser, Bülent Behlül, Kuku, İrfan, Yılmaz Yaşar, Hamiyet, Kurtoğlu, Erdal, Demircioğlu, Sinan, Pekkolay, Zafer, İlhan, Osman, Tokgözoğlu, Lale
Format: Article
Language:English
Subjects:
Global severity index
HoFH
Homozygous familial hypercholesterolemia
LDL
LDL apheresis
Mental state
Physical activity
Psychiatry
Psychopathology
Symptom check list
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Summary:Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening disease due to high serum low-density lipoprotein (LDL) cholesterol levels. LDL cholesterol–lowering interventions are fundamental for patients with HoFH. It was aimed to investigate the association between the mental status of patients with HoFH and healthy lifestyle behaviors. This subgroup analysis of the A-HIT1 population included the data of patients aged ≥18 years with a clinical diagnosis of HoFH undergoing therapeutic LDL apheresis. Besides the demographic and clinical characteristics of patients, healthy lifestyle behaviors were assessed, and psychiatric symptoms were screened by Symptom Check List (SCL-90-R). The highest percentage for pathology was observed in dimensions of obsessive-compulsive, somatization, interpersonal sensitivity, and depression in SCL-90-R. Patients with any cardiovascular condition have more psychiatric symptoms in different fields of SCL-90-R. The outcomes of the correlative analysis indicated that lower the age of the first coronary event better the psychiatric status, probably denoting a better adaptation to disease and its treatment. Among 68 patients, 36 patients were not exercising regularly. Patients with regular physical activity had significantly lower scores in most dimensions of SCL-90-R and there was no association between regular physical activity and other investigated variables. The strongest predictor of regular exercising was global severity index of SCL-90-R. In the HoFH population, there was a high prevalence of mental disturbances. Better psychiatric status was associated with regular exercising. Therefore, assessing the mental status of patients with HoFH and referring patients in need, to a psychiatrist, may improve the outcome of patients. •HoFH patients with any cardiovascular condition have more psychiatric symptoms.•Lower age of first coronary event is related to better psychiatric status.•HoFH patients with better mental state are more likely to exercise regularly.
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2020.04.006