SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo

The overexpression of SOX4 in various kinds of cancer cells was associated with poor prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular carcinoma (HCC). In our study, the clinic...

Full description

Saved in:
Bibliographic Details
Published in:Oncogene 2020-06, Vol.39 (24), p.4695-4710
Main Authors: Tsai, Chi-Neu, Yu, Shu-Chuan, Lee, Chao-Wei, Pang, Jong-Hwei Su, Wu, Chun-Hsin, Lin, Sey-En, Chung, Yi-Hsiu, Tsai, Chia-Lung, Hsieh, Sen-Yung, Yu, Ming-Chin
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Blood clot
Breast cancer
Cancer
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell adhesion & migration
Cell Line, Tumor
Cell migration
Cell Movement
Chemokine CXCL12 - genetics
Chemokine CXCL12 - metabolism
Chemotaxis
Chromatin
CRISPR
CRISPR-Cas Systems
CXCL12 protein
CXCR4 protein
Development and progression
Ectopic expression
Endothelial cells
Endothelium
Hepatocellular carcinoma
Hepatoma
Human Umbilical Vein Endothelial Cells - metabolism
Human Umbilical Vein Endothelial Cells - pathology
Humans
Immunoprecipitation
Liver cancer
Liver Neoplasms, Experimental - blood supply
Liver Neoplasms, Experimental - genetics
Liver Neoplasms, Experimental - metabolism
Liver Neoplasms, Experimental - pathology
Male
Medical prognosis
Metastases
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neovascularization
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Oncology, Experimental
Patients
Prognosis
SOXC Transcription Factors - genetics
SOXC Transcription Factors - metabolism
Thrombosis
Thrombosis - genetics
Thrombosis - metabolism
Thrombosis - pathology
Tumor microenvironment
Tumor Microenvironment - genetics
Tumors
Umbilical vein
Vascularization
Xenografts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The overexpression of SOX4 in various kinds of cancer cells was associated with poor prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular carcinoma (HCC). In our study, the clinical relevance of SOX4 overexpression in HCC and its role in the tumor microenvironment were investigated. The overexpression of SOX4 (SOX4 ) in tumor lesions was associated with higher microvessel density (P = 0.012), tumor thrombosis formation (P = 0.012), distant metastasis (P 
ISSN:0950-9232
1476-5594
DOI:10.1038/s41388-020-1319-z