Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine

Adenosine and adenosine triphosphate (ATP) are widely used to induce hyperemia for fractional flow reserve (FFR) measurements. Caffeine attenuates their hyperemic effects, but not those of nicorandil and papaverine. No studies have systematically compared the hyperemic efficacies of nicorandil, papa...

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Bibliographic Details
Published in:International journal of cardiology 2020-09, Vol.314, p.1-6
Main Authors: Matsumoto, Hidenari, Mikuri, Mikiko, Masaki, Ryota, Tanaka, Hideaki, Ogura, Kunihiro, Arai, Taitou, Sakai, Rikuo, Oishi, Yosuke, Okada, Natsumi, Shinke, Toshiro
Format: Article
Language:English
Subjects:
Coronary Angiography
Coronary Circulation
Coronary hyperemia
Coronary Stenosis
Feasibility Studies
Fractional flow reserve
Fractional Flow Reserve, Myocardial
Humans
Hyperemia - chemically induced
Nicorandil
Papaverine - pharmacology
Vasodilator Agents - pharmacology
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Summary:Adenosine and adenosine triphosphate (ATP) are widely used to induce hyperemia for fractional flow reserve (FFR) measurements. Caffeine attenuates their hyperemic effects, but not those of nicorandil and papaverine. No studies have systematically compared the hyperemic efficacies of nicorandil, papaverine, and ATP with and without caffeine abstention. FFRs were measured using nicorandil 2 mg (FFRNC2), nicorandil 4 mg (FFRNC4), and papaverine (FFRPAP) in 40 patients (group 1), and using nicorandil 2 mg, ATP (FFRATP), ATP plus nicorandil (FFRATP+NC2), and papaverine in 20 patients with (group 2) and in 20 patients without caffeine abstention (group 3). In group 1, FFRNC2 and FFRNC4 did not differ (p = 0.321) and were higher than FFRPAP (p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2020.05.013