Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis

Background and purpose Myeloperoxidase (MPO) is an important oxidative enzyme participating in different stages of cardiovascular disease and predicts prognosis. Little is known about its role in acute cerebrovascular events and carotid plaque vulnerability. In this study, the aim was to assess plas...

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Bibliographic Details
Published in:European journal of neurology 2020-08, Vol.27 (8), p.1604-1611
Main Authors: Orion, D., Landenberg, P., Itsekson‐Hayosh, Z., Schwammenthal, Y., Tsabari, R., Merzeliak, O., Chapman, J., Tanne, D.
Format: Article
Language:English
Subjects:
Brain
Cardiovascular diseases
Carotid artery
carotid stenosis
Discharge
Interleukins
Ischemia
Peroxidase
Plasma
plasma marker
Stenosis
Stroke
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Summary:Background and purpose Myeloperoxidase (MPO) is an important oxidative enzyme participating in different stages of cardiovascular disease and predicts prognosis. Little is known about its role in acute cerebrovascular events and carotid plaque vulnerability. In this study, the aim was to assess plasma MPO levels in acute stroke patients and their correlation to stroke severity and stroke outcome. Methods Plasma MPO levels were assessed in patients presenting with acute brain ischaemia within 36 h of symptom onset (n = 144, mean age 64.7 ± 11.6 years, 67% men) and in patients with moderate‐to‐severe carotid stenosis undergoing carotid artery stenting (n = 51, mean age 66.3 ± 8.4 years, 75% men). Patients presenting with acute brain ischaemia were assessed serially for stroke severity and disability. Results Plasma MPO concentrations (ng/ml) were associated with interleukin‐6 (r = 0.38, P  10, bottom, middle and top tertiles 6.3%, vs. 41.7% and 31.3%, respectively; P 
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.14279