Purine-blended nanofiber woven flexible nanomats for SERS-based analyte detection

Flexible and free-standing polymeric fibers, coupled with metal nanoparticles, present an excellent opportunity for highly sensitive surface-enhanced Raman scattering (SERS) spectroscopy-based detection platforms. Such host matrices are prepared by only a few preferred methods, followed by induction...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (43), p.5795-5798
Main Authors: Saravanan, R. Kamal, Naqvi, Tania K, Patil, Sandip, Dwivedi, Prabhat K, Verma, Sandeep
Format: Article
Language:English
Subjects:
Aqueous solutions
Gold
Kidney diseases
Nanofibers
Nanoparticles
Platforms
Polymer blends
Raman spectra
Raman spectroscopy
Sensitivity
Substrates
Uric acid
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Summary:Flexible and free-standing polymeric fibers, coupled with metal nanoparticles, present an excellent opportunity for highly sensitive surface-enhanced Raman scattering (SERS) spectroscopy-based detection platforms. Such host matrices are prepared by only a few preferred methods, followed by induction of metal nanoparticle aggregation in a protected environment to afford functional SERS platforms. We provide an interesting advance in this area by choosing a thiol-modified purine ( L )-polymer blend, obtained through the electrospinning process, for directed decoration with gold nanoparticles. The described SERS purine-nanomat substrate enables the detection of uric acid, an important indicator of gout, preeclampsia, cardiovascular and kidney diseases, in aqueous solution up to 100 nM, with good stability and high sensitivity, offering superiority over existing techniques in terms of sensitivity and cost-effectiveness. We report a fabricated nanocomposite as a flexible Surface-Enhanced Raman Scattering (SERS) substrate for uric acid detection up to 10 −7 M (100 nM).
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc00648c