Cutaneous manifestations of internal malignancy

Summary Skin lesions associated with internal malignancy may present as cutaneous metastases or as typical lesions occurring in the context of certain cancer‐associated genetic syndromes. Paraneoplastic syndromes, on the other hand, are only indirectly associated with an underlying malignancy and ar...

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Bibliographic Details
Published in:Journal der Deutschen Dermatologischen Gesellschaft 2020-05, Vol.18 (5), p.456-469
Main Authors: Alter, Mareike, Mengoni, Miriam, Gaffal, Evelyn
Format: Article
Language:English
Subjects:
Autoimmune diseases
Humans
Malignancy
Metastases
Neoplasms - complications
Paraneoplastic Syndromes - diagnosis
Paraneoplastic Syndromes - pathology
Skin diseases
Skin Diseases - diagnosis
Skin Diseases - etiology
Skin lesions
Skin Neoplasms - secondary
Tumors
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Summary:Summary Skin lesions associated with internal malignancy may present as cutaneous metastases or as typical lesions occurring in the context of certain cancer‐associated genetic syndromes. Paraneoplastic syndromes, on the other hand, are only indirectly associated with an underlying malignancy and are not malignant per se. Historically, a distinction has been made between “obligate” and “facultative” paraneoplastic disorders, depending on the likelihood with which they are potentially associated with malignancy. In addition, there are nonspecific cutaneous manifestations that are only rarely associated with an underlying malignancy. Another possible classification is based on the pathophysiological mechanisms underlying the cutaneous lesions. In everyday practice, it is essential that dermatologists recognize potentially cancer‐associated dermatoses, as this will frequently contribute to the initial diagnosis of an underlying neoplasm.
ISSN:1610-0379
1610-0387
DOI:10.1111/ddg.14093