CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression

The progression of the human immunodeficiency virus (HIV) infection to acquired immunodeficiency syndrome (AIDS) can be efficiently interrupted by antiretroviral therapy (ART). However, even successfully treated HIV‐infected individuals are prone to develop non‐AIDS‐related diseases that affect the...

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Bibliographic Details
Published in:Journal of medical virology 2020-12, Vol.92 (12), p.3254-3264
Main Authors: Passos, Daniela F., Bremm, João M., Silveira, Leonardo L., Jantsch, Matheus H., Silva, Jean L. G., Disconzi, Enzo, Rezer, João F. P., Schwarzbold, Alexandre V., Marques, Angela C. F., Schetinger, Maria R. C., Leal, Daniela B. R.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
Aged
Aging
Aging - immunology
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
Biomarkers
CD4 antigen
CD4 Lymphocyte Count
CD4-CD8 Ratio
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cognition
comorbidities
Comorbidity
Disorders
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
Human immunodeficiency virus
Humans
Infections
Lymphocytes
Lymphocytes T
Male
Metabolism
Middle Aged
Organs
Sustained Virologic Response
Viral Load
Virology
Viruses
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Summary:The progression of the human immunodeficiency virus (HIV) infection to acquired immunodeficiency syndrome (AIDS) can be efficiently interrupted by antiretroviral therapy (ART). However, even successfully treated HIV‐infected individuals are prone to develop non‐AIDS‐related diseases that affect the metabolism and several organs and systems. Biomarkers that predict the occurrence of comorbidities may help develop preventive measures. Current research shows that CD4+ T cell counts and viral load do not predict the development of non‐AIDS‐related diseases. The CD4/CD8 ratio has been indicated as a suitable marker of persistent immune dysfunction and the occurrence of non‐AIDS‐related events in treated HIV‐positive patients. In this study, we explored the relationship between CD4/CD8 ratios, comorbidities, and aging in ART‐treated HIV patients on viral suppression. We collected and evaluated data from 352 HIV‐positive adults who were virologically suppressed (
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25911