Differentiation of regenerative nodule, dysplastic nodule, and small hepatocellular carcinoma in cirrhotic patients: a contrast-enhanced ultrasound–based multivariable model analysis

Objective To develop a contrast-enhanced ultrasound (CEUS)–based model for differentiating cirrhotic liver lesions and for active surveillance of hepatocellular carcinoma (HCC). Methods Patients with focal liver lesions (FLLs) with biopsy/resection-proven pathology and pre-procedure CEUS were enroll...

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Bibliographic Details
Published in:European radiology 2020-09, Vol.30 (9), p.4741-4751
Main Authors: Duan, Yu, Xie, Xiaoyan, Li, Qian, Mercaldo, Nathaniel, Samir, Anthony E., Kuang, Ming, Lin, Manxia
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Cirrhosis
Contrast Media
Diagnosis, Differential
Diagnostic Radiology
Female
Hepatobiliary-Pancreas
Hepatocellular carcinoma
Humans
Imaging
Internal Medicine
Interventional Radiology
Lesions
Liver
Liver - diagnostic imaging
Liver - pathology
Liver cancer
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver Neoplasms - complications
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Nodules
Prediction models
Radiology
Ranking
Reduction
Regression analysis
Regression models
Retrospective Studies
Surveillance
Ultrasonic imaging
Ultrasonography - methods
Ultrasound
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Summary:Objective To develop a contrast-enhanced ultrasound (CEUS)–based model for differentiating cirrhotic liver lesions and for active surveillance of hepatocellular carcinoma (HCC). Methods Patients with focal liver lesions (FLLs) with biopsy/resection-proven pathology and pre-procedure CEUS were enrolled from our institution between January 2011 and November 2014. Univariable and multivariable regression models were constructed using qualitative CEUS features and/or contrast arrival time ratio (CAT R ). The optimism-adjusted Harrell’s generalized concordance index (C H ) was used to quantify the discriminatory ability of each CEUS feature and model. Results A total of 149 patients (113 men and 36 women) with 162 FLLs were enrolled with mean age 53.4 ± 12.7 years. A 0.1-unit reduction in CAT R was associated with a 68% increase in the odds of having a higher nodule ranking (RN 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-020-06834-5