Circuits and functions of the lateral habenula in health and in disease

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain's 'antireward...

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Bibliographic Details
Published in:Nature reviews. Neuroscience 2020-05, Vol.21 (5), p.277-295
Main Authors: Hu, Hailan, Cui, Yihui, Yang, Yan
Format: Article
Language:English
Subjects:
Animal models
Animals
Basal ganglia
Basal Ganglia - physiology
Basal Ganglia - physiopathology
Circuits
Cognitive ability
Dopamine receptors
Forebrain
Habenula
Habenula - physiology
Habenula - physiopathology
Health
Health aspects
Humans
Limbic System - physiology
Limbic System - physiopathology
Luteinizing hormone
Major depressive disorder
Mental depression
Mental disorders
Mental Disorders - physiopathology
Mesencephalon
Mesencephalon - physiology
Mesencephalon - physiopathology
Motivation
Neural circuitry
Neural networks
Neural Pathways - physiology
Neural Pathways - physiopathology
Neurophysiology
Norepinephrine
Risk factors
Withdrawal
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Summary:The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. Its unique anatomical position enables the LHb to act as a hub that integrates value-based, sensory and experience-dependent information to regulate various motivational, cognitive and motor processes. Dysfunction of the LHb may contribute to the pathophysiology of several psychiatric disorders, especially major depression. Recently, exciting progress has been made in identifying the molecular and cellular mechanisms in the LHb that underlie negative emotional state in animal models of drug withdrawal and major depression. A future challenge is to translate these advances into effective clinical treatments.
ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/s41583-020-0292-4