Controlled synthesis of upconverting nanoparticles/CuS yolk-shell nanoparticles for in vitro synergistic photothermal and photodynamic therapy of cancer cells

Synergistic photodynamic and photothermal therapy of cancer cells is of considerable scientific and technological interest. In this work, we demonstrate a sacrificial template strategy to fabricate yolk-shell nanoparticles combining upconversion nanoparticles (UCNPs) and CuS nanoparticles. Lanthanid...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017, Vol.5 (48), p.9487-9496
Main Authors: Huang, Chen-Xi, Chen, Hua-Jian, Li, Fei, Wang, Wan-Ni, Li, Dong-Dong, Yang, Xian-Zhu, Miao, Zhao-Hua, Zha, Zheng-Bao, Lu, Yang, Qian, Hai-Sheng
Format: Article
Language:English
Subjects:
Cancer
Cell death
Copper sulfides
Energy transfer
Erbium
Fluorescence
Fluorides
Free radicals
Hydroxyl radicals
Infrared radiation
Lasers
Magnetic resonance imaging
Nanoparticles
Nanospheres
Oxygen
Photodynamic therapy
Precision medicine
Reactive oxygen species
Singlet oxygen
Sodium compounds
Synergistic effect
Upconversion
Yolk
Ytterbium
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Summary:Synergistic photodynamic and photothermal therapy of cancer cells is of considerable scientific and technological interest. In this work, we demonstrate a sacrificial template strategy to fabricate yolk-shell nanoparticles combining upconversion nanoparticles (UCNPs) and CuS nanoparticles. Lanthanide-doped upconversion nanoparticles of NaYF :30% Yb,1% Nd,0.5% Er@NaYF :20% Nd (also denoted as UCNPs) have been prepared as 808 nm light excited remote-controlled nanotransducers for in vitro cancer cell treatment. The upconversion fluorescence of the as-prepared UCNPs@CuS yolk-shell nanoparticles is completely quenched under the excitation of an 808 nm laser, which demonstrates that the energy transfer between the UCNPs and CuS is very efficient. In addition, the as-prepared UCNPs@CuS nanoparticles show higher production ability for hydroxyl radicals (˙OH) and singlet oxygen ( O ) compared to CuS hollow nanospheres of similar size. In particular, the excited shell layer (CuS) showed an enhanced photothermal effect while producing reactive oxygen species (ROS) including singlet oxygen ( O ) and hydroxyl radicals (˙OH) after being exposed to near infrared (NIR) light. Thus, the as-prepared UCNPs@CuS yolk-shell nanoparticles exhibited the synergistic effect of photothermal and photodynamic therapy of cancer cells, which resulted in significant cell death after exposure to an 808 nm laser. The synthetic strategy will provide an alternative method to fabricate other UCNP based core-shell nanoparticles for potential and important applications in bionanotechnology including theranostics, multimodal treatment, magnetic resonance imaging-guided photodynamic therapy, etc.
ISSN:2050-750X
2050-7518
DOI:10.1039/c7tb02733h