Intracellular pH-induced fluorescence used to track nanoparticles in cells

A nanoparticle with pH-induced fluorescence was reported for intracellular tracking. The fluorescence was evoked by the isomerization of the ring-closed form spiropyran (SP) to the ring-open form merocyanine (MC) in the weak acidic environment of cells. The SP-MC switch accelerated the dissociation...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-07, Vol.3 (27), p.5411-5414
Main Authors: Cheng, F R, Chen, Y, Su, T, Cao, H, Li, S, Cao, J, He, B, Gu, Z W, Luo, X L
Format: Article
Language:English
Subjects:
Biology
Fluorescence
Isomerization
Medicine
Nanoparticles
Spiropyrans
Switches
Tracking
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Summary:A nanoparticle with pH-induced fluorescence was reported for intracellular tracking. The fluorescence was evoked by the isomerization of the ring-closed form spiropyran (SP) to the ring-open form merocyanine (MC) in the weak acidic environment of cells. The SP-MC switch accelerated the dissociation of nanoparticles to trigger the release of trapped paclitaxel.
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb00756a