Compatibility of treprostinil sodium and dopamine hydrochloride during simulated Y-site administration

To evaluate the physical and chemical compatibilities of treprostinil sodium and dopamine hydrochloride. Treprostinil sodium (4,000, 76,000, and 500,000 ng/mL) were mixed with dopamine hydrochloride (0.6, 3.2, 6, and 40 mg/mL). Samples were obtained at hours 0, 1, 2, and 4 for physical compatibility...

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Bibliographic Details
Published in:American journal of health-system pharmacy 2020-04, Vol.77 (8), p.649-657
Main Authors: Bustin, Anna, Ramsey, E Zachary, Hanna, Brian D, Kaushal, Gagan
Format: Article
Language:English
Subjects:
Administration, Intravenous
Antihypertensive Agents - chemistry
Dopamine - chemistry
Dopamine Agents - chemistry
Drug Incompatibility
Epoprostenol - analogs & derivatives
Epoprostenol - chemistry
Hydrogen-Ion Concentration
Time Factors
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Summary:To evaluate the physical and chemical compatibilities of treprostinil sodium and dopamine hydrochloride. Treprostinil sodium (4,000, 76,000, and 500,000 ng/mL) were mixed with dopamine hydrochloride (0.6, 3.2, 6, and 40 mg/mL). Samples were obtained at hours 0, 1, 2, and 4 for physical compatibility and chemical stability testing. Physical compatibility was assessed by visual examination and measurements of turbidity and pH. Drug concentrations were assessed using stability-indicating liquid chromatography mass spectrophotometry (LCMS) for treprostinil sodium and stability-indicating high-performance liquid chromatography (HPLC) for dopamine hydrochloride. Treprostinil sodium 4,000 and 76,000 ng/mL, when mixed with dopamine hydrochloride 0.6, 3.2, 6, and 40 mg/mL, were stable for 4 hours. Treprostinil sodium 500,000 ng/mL was stable when mixed with dopamine hydrochloride 0.6 mg/mL for 4 hours, but when mixed with dopamine hydrochloride 3.2, 6, and 40 mg/mL, significant precipitation was seen. Treprostinil sodium 4,000 and 76,000 ng/mL were stable for 4 hours during simulated Y-site coadministration with dopamine hydrochloride 0.6, 3.2, 6, and 40 mg/mL. Treprostinil sodium 500,000 ng/mL is stable when mixed with dopamine hydrochloride 0.6 mg/mL.
ISSN:1079-2082
1535-2900
DOI:10.1093/ajhp/zxaa025