Kosen-cha, a Polymerized Catechin-Rich Green Tea, as a Potential Functional Beverage for the Reduction of Body Weight and Cardiovascular Risk Factors: A Pilot Study in Obese Patients

Previous studies have shown that green tea catechins (GTCs) have beneficial effects on obesity and metabolic syndromes. In this study, we prepared kosen-cha from green tea using high pressure extraction, to reduce the astringent taste of the green tea. We identified a large quantity of polymerized G...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2020/04/01, Vol.43(4), pp.675-681
Main Authors: Katanasaka, Yasufumi, Miyazaki, Yusuke, Sunagawa, Yoichi, Funamoto, Masafumi, Shimizu, Kana, Shimizu, Satoshi, Sari, Nurmila, Shimizu, Yasuo, Wada, Hiromichi, Hasegawa, Koji, Morimoto, Tatsuya
Format: Article
Language:eng ; jpn
Subjects:
Ankle
Body composition
Body mass index
Body weight
Brain natriuretic peptide
cardiovascular disease
Cardiovascular diseases
Catechin
Green tea
Heart
Homeostasis
Hypertrophy
Insulin
Insulin resistance
kosen-cha
Lipids
Metabolic syndrome
Metabolism
Obesity
polymerized green tea catechin
Risk factors
Serum lipids
Tea
Ventricle
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Summary:Previous studies have shown that green tea catechins (GTCs) have beneficial effects on obesity and metabolic syndromes. In this study, we prepared kosen-cha from green tea using high pressure extraction, to reduce the astringent taste of the green tea. We identified a large quantity of polymerized GTCs in kosen-cha. To investigate the effects of kosen-cha containing polymerized GTCs in obese Japanese patients, we designed an open-label pilot study in which 6 obese subjects (body mass index (BMI) >25 kg/m2) were administered kosen-cha (5 g/L/d) for 12 weeks. Body composition, serum lipids, insulin resistance, vascular functions, and cardiac hypertrophy were measured before and 12 weeks after kosen-cha administration. Kosen-cha showed no significant adverse effects on the patients. Body weights, BMI, waist circumferences, serum triglyceride (TG) levels, and homeostasis model assessment as an index of insulin resistance (HOMA-IR) levels were significantly decreased after the 12 weeks of administration. Flow-mediated dilation (FMD) (p = 0.0214), brachial-ankle pulse wave velocity (baPWV)(p = 0.0141), left ventricular mass indexes (p = 0.0120), and plasma brain natriuretic peptide (BNP) (p = 0.0144) were significantly improved. Overall, kosen-cha reduced obesity and improved insulin resistance, vascular function, and cardiac hypertrophy, indicating its preventive potential in obesity and metabolic syndrome.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b19-00921