One-Pot Amberlyst 15-Controlled Cyclocondensation of Piperidines and Arylaldehydes: Synthesis of 3,5-Diarylmethylpyridines

Amberlyst 15-controlled one-pot easy-operational intermolecular cyclocondensation of substituted piperidines with arylaldehydes provides diversified 3,5-diarylmethylpyridines in high to excellent yields under refluxing toluene conditions. The uses of various acidic solid supports and reaction solven...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-04, Vol.85 (8), p.5651-5659
Main Authors: Chang, Meng-Yang, Tsai, Yu-Lin
Format: Article
Language:English
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Summary:Amberlyst 15-controlled one-pot easy-operational intermolecular cyclocondensation of substituted piperidines with arylaldehydes provides diversified 3,5-diarylmethylpyridines in high to excellent yields under refluxing toluene conditions. The uses of various acidic solid supports and reaction solvents are investigated for facile and efficient transformation. A plausible mechanism has been proposed.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b03315