Nanoscale poly(acrylic acid)-based hydrogels prepared via a green single-step approach for application as low-viscosity biomimetic fluid tears

The present work reports a nanotechnology strategy to prepare a low-viscosity poly(acrylic acid) (PAAc)-based tear substitute with enhanced efficacy and compliance. Specifically, nanogels composed of PAAc and polyvinylpyrrolidone (PVP) were prepared by adapting an ionizing radiation method. For this...

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Bibliographic Details
Published in:Materials Science & Engineering C 2020-05, Vol.110, p.110726-110726, Article 110726
Main Authors: Swilem, Ahmed E., Elshazly, Amany H.M., Hamed, Ashraf A., Hegazy, El-Sayed A., Abd El-Rehim, Hassan A.
Format: Article
Language:English
Subjects:
Acrylic acid
Acrylic Resins - chemistry
Acrylic Resins - pharmacology
Acrylics
Animals
Biomimetic Materials - chemistry
Biomimetic Materials - pharmacology
Biomimetics
Cornea
Crosslinking
Disease Models, Animal
Dry eye
Dry Eye Syndromes - drug therapy
Dry Eye Syndromes - metabolism
Epithelium
Feed composition
Gamma rays
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogen bonding
Ionizing radiation
Irradiation
Light scattering
Lubricant Eye Drops - chemistry
Lubricant Eye Drops - pharmacology
Materials science
Mucoadhesion
Nanogel
Nanoparticles
Nanotechnology
Photon correlation spectroscopy
Poly(acrylic acid)
Polyacrylic acid
Polyvinylpyrrolidone
Rabbits
Radiation dosage
Radiation effects
Substitutes
Tear substitute
Tears
Vinylpyrrolidone
Viscosity
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Summary:The present work reports a nanotechnology strategy to prepare a low-viscosity poly(acrylic acid) (PAAc)-based tear substitute with enhanced efficacy and compliance. Specifically, nanogels composed of PAAc and polyvinylpyrrolidone (PVP) were prepared by adapting an ionizing radiation method. For this purpose, different aqueous systems: PVP/PAAc nanoparticulate complexes, PVP/acrylic acid (AAc), N-vinylpyrrolidone (N-VP)/PAAc, and N-VP/AAc were exposed to gamma rays. The dynamic light scattering technique showed that stable nanogels are only produced in a relatively high yield from the PVP/AAc system. Nanogel formation was driven by the hydrogen-bonding complexation between PVP and PAAc (formed in situ) as well as the radiation-induced cross-linking. Transparency, viscosity and mucoadhesiveness of emerged nanogels were optimized by controlling the feed composition and irradiation dose. Furthermore, neutralized nanogels were topically applied in a dry eye model and compared with a PAAc-based commercial tear substitute, namely Vidisic® Gel. The results of Schirmer's test and tear break-up time demonstrated that nanogels prepared from AAc-rich feed solutions at 20 kGy enhanced markedly the dry eye conditions. The histopathological analysis also ensured the competence of PAAc-rich nanogels to completely return the corneal epithelium to its normal state. [Display omitted] •Polyvinylpyrrolidone-poly(acrylic acid) (PVP/PAAc) nanogels were prepared by gamma rays for application as tear substitutes.•Particle size and swellability of nanogels were controlled through feed composition and irradiation dose.•Stability and pH responsiveness of nanogels were established.•Neutralized nanogels displayed proper transmittance, rheological and mucoadhesive properties.•PAAc-rich nanogels prepared at 20 kGy showed better efficacy in treating a dry eye model as compared to Vidisic® gel.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2020.110726