Diabetic versus non‐diabetic rhino‐orbito‐cerebral mucormycosis

Summary Objective To compare the characteristics and outcomes of rhino‐orbito‐cerebral mucormycosis (ROCM) in diabetic versus non‐diabetic patients. Method It is a retrospective comparative case series on consecutive patients with biopsy‐proven ROCM. Systemic and ophthalmic manifestations, imaging,...

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Bibliographic Details
Published in:Mycoses 2020-06, Vol.63 (6), p.573-578
Main Authors: Abdolalizadeh, Parya, Kashkouli, Mohsen Bahmani, Khademi, Behzad, Karimi, Nasser, Hamami, Parisa, Es'haghi, Acieh
Format: Article
Language:English
Subjects:
Adult
Aged
Antifungal Agents - therapeutic use
Biopsy
Brain Diseases - drug therapy
Brain Diseases - microbiology
Brain Diseases - mortality
Diabetes
Diabetes Complications - microbiology
Diabetes mellitus
Diabetes Mellitus - epidemiology
exenteration
Female
globe survival
Hospitals, University
Humans
Iran - epidemiology
Male
Middle Aged
Mortality
Mucormycosis
Mucormycosis - classification
Mucormycosis - drug therapy
Mucormycosis - mortality
Mucormycosis - physiopathology
Orbital Diseases - drug therapy
Orbital Diseases - microbiology
Orbital Diseases - mortality
Retrospective Studies
Survival
Vision
vision survival
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Summary:Summary Objective To compare the characteristics and outcomes of rhino‐orbito‐cerebral mucormycosis (ROCM) in diabetic versus non‐diabetic patients. Method It is a retrospective comparative case series on consecutive patients with biopsy‐proven ROCM. Systemic and ophthalmic manifestations, imaging, management and final outcomes were compared between diabetic versus non‐diabetic ROCMs referred the eye clinic of a university‐based hospital (2008‐2016). Results Forty‐three diabetics (55 eyes) with mean age of 54.6 (SD:12.5) years and 20 non‐diabetics (24 eyes) with mean age of 57.5 (SD:13.8) years were enrolled. Patients' survival was observed in 51% of diabetics and 70% of non‐diabetics (P = .1). The mortality rate was 7.4 times (CI95%: 1.85‐29.96) higher in diabetic ROCM treated with non‐liposomal amphotericin (P = .01). Exenteration did not significantly change the mortality rate in either group. Globe survival was 40% and 50% in diabetics and non‐diabetics (P = 1), respectively. Vision survival was observed in 20% of diabetics and 37% of non‐diabetics (P = .2). Conclusion Patients', globe and vision survivals were not different between diabetic and non‐diabetic patients with ROCM. They were 51%, 40% and 20% in diabetic and 70%, 50% and 37% in non‐diabetic ROCM.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.13078