Prevalence, clinical course, and predictive factors of immune checkpoint inhibitor monotherapy‐associated hepatitis in Japan

Background and Aim Immune checkpoint inhibitors (ICI) have revolutionized anti‐malignancy therapy and thus have been increasingly used. Although ICI may cause immune‐related adverse events (irAE) in various organs, including the liver, the prevalence and predictive factors of irAE have not been clar...

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Published in:Journal of gastroenterology and hepatology 2020-10, Vol.35 (10), p.1782-1788
Main Authors: Kitagataya, Takashi, Suda, Goki, Nagashima, Kazunori, Katsurada, Takehiko, Yamamoto, Koji, Kimura, Megumi, Maehara, Osamu, Yamada, Ren, Shigesawa, Taku, Suzuki, Kazuharu, Nakamura, Akihisa, Ohara, Masatsugu, Umemura, Machiko, Kawagishi, Naoki, Nakai, Masato, Sho, Takuya, Natsuizaka, Mitsuteru, Morikawa, Kenichi, Ogawa, Koji, Ohnishi, Shunsuke, Komatsu, Yoshito, Hata, Hiroo, Takeuchi, Satoshi, Abe, Takashige, Sakakibara‐Konishi, Jun, Teshima, Takanori, Homma, Akihiro, Sakamoto, Naoya
Format: Article
Language:English
Subjects:
adverse events
Chemotherapy
Corticosteroids
female
Hepatitis
immune checkpoint inhibitor
Immune checkpoint inhibitors
immune system
irAE
Malignancy
Monoclonal antibodies
Mycophenolate mofetil
Mycophenolic acid
Patients
Pembrolizumab
risk factor
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Summary:Background and Aim Immune checkpoint inhibitors (ICI) have revolutionized anti‐malignancy therapy and thus have been increasingly used. Although ICI may cause immune‐related adverse events (irAE) in various organs, including the liver, the prevalence and predictive factors of irAE have not been clarified. Methods In this retrospective study, consecutive patients who had malignancies and were treated with ICI without other chemotherapeutic agents at Hokkaido University Hospital between 2014 and 2019 were screened. Patients were excluded if they were
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.15041