A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

Background and purpose The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α‐synuclein (α‐syn) in plasma neuronal exosomes as a biomarker for early PD diagnosis and disease progression. Metho...

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Bibliographic Details
Published in:European journal of neurology 2020-06, Vol.27 (6), p.967-974
Main Authors: Niu, M., Li, Y., Li, G., Zhou, L., Luo, N., Yao, M., Kang, W., Liu, J.
Format: Article
Language:English
Subjects:
alpha-Synuclein - blood
Behavior disorders
biomarker
Biomarkers
Correlation analysis
Cross-Sectional Studies
Diagnosis
Diagnostic systems
disease progression
Electrochemiluminescence
Exosomes
Eye movements
Gender
Humans
idiopathic rapid eye movement sleep behavior disorder
Immunoassay
Longitudinal Studies
Movement disorders
Neurodegenerative diseases
neuronal exosome
Parkinson Disease - diagnosis
Parkinson's disease
Plasma
Regression analysis
REM sleep
Sleep
Sleep disorders
Statistical analysis
Subgroups
Synuclein
α‐synuclein
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Summary:Background and purpose The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α‐synuclein (α‐syn) in plasma neuronal exosomes as a biomarker for early PD diagnosis and disease progression. Methods This study included both cross‐sectional and longitudinal designs. The subjects included 36 patients with early‐stage PD, 17 patients with advanced PD, 20 patients with idiopathic rapid eye movement sleep behavior disorder and 21 healthy controls (HCs). α‐syn levels were measured by electrochemiluminescence immunoassay. A subgroup of patients with early‐stage PD (n = 18) participated in a follow‐up examination with repeated blood collection and clinical assessments after an average of 22 months. Results The α‐syn levels in plasma neuronal exosomes were significantly higher in patients with early‐stage PD compared with HCs (P = 0.007). Differences in α‐syn levels between patients with idiopathic rapid eye movement sleep behavior disorder and HCs did not reach statistical significance (P = 0.08). In addition, Spearman correlation analysis revealed that neuronal exosomal α‐syn concentrations were correlated with Movement Disorders Society Unified Parkinson's Disease Rating Scale III/(I + II + III) scores, Non‐Motor Symptom Questionnaire scores and Sniffin' Sticks 16‐item test scores of patients with PD (P 
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.14208