Ficolin‐1 gene (FCN1) −144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under‐five Egyptian children: A multicenter study

Background Pneumonia is the foremost cause of child death worldwide. M‐ficolin is encoded by the FCN1 gene and represents a novel link between innate and adaptive immunity. Objectives To investigate the FCN1 −144 C/A (rs10117466) polymorphism as a potential marker for pneumonia severity and adverse...

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Published in:Pediatric pulmonology 2020-05, Vol.55 (5), p.1175-1183
Main Authors: Elkoumi, Mohamed A., Abdellatif, Sawsan H., Mohamed, Faisal Y., Sherif, Ahmed H., Elashkar, Shaimaa S. A., Saleh, Rabab M., Boraey, Naglaa F., Abdelaal, NourEldin M., Akeel, Nagwa E., Elhewala, Ahmed A., Mosbah, Amira A., Zakaria, Mervat T., Soliman, Mohammed M., Salah, Ahmed, Sedky, Yasser M., Sobieh, Alaa A., Mashali, Mohamed H., Waked, Nevin M., Elshreif, Anas M., Hafez, Sahbaa F., Hashem, Mustafa I. A., Shehab, Mohamed M., Soliman, Attia A., Emam, Ahmed A., Ahmed, Abdelrahman A. A., Fahim, Mohamed S., Elshehawy, Naglaa A., Abdel‐Aziz, Marwa M., Abdou, Adel M., El‐Shehawy, Ahmed A., Youssef, Manal A. A., Fahmy, Dalia S., Malek, Mai M., Osman, Sherif F., Ibrahim, Mohamed A. M., Alanwar, Mohamed I., Zeidan, Nancy M. S.
Format: Article
Language:English
Subjects:
adverse outcome
Child, Preschool
Egypt - epidemiology
Female
Ficolins
ficolin‐1 gene
gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Humans
Infant
Lectins - blood
Lectins - genetics
Male
Odds Ratio
Pneumonia
Pneumonia - blood
Pneumonia - epidemiology
Pneumonia - genetics
Polymorphism
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Prospective Studies
Risk Factors
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Summary:Background Pneumonia is the foremost cause of child death worldwide. M‐ficolin is encoded by the FCN1 gene and represents a novel link between innate and adaptive immunity. Objectives To investigate the FCN1 −144 C/A (rs10117466) polymorphism as a potential marker for pneumonia severity and adverse outcome namely complications or mortality in the under‐five Egyptian children. Methods This was a prospective multicenter study that included 620 children hospitalized with World Health Organization‐defined severe pneumonia and 620 matched healthy control children. Polymorphism rs10117466 of the FCN1 gene promoter was analyzed by PCR‐SSP, while serum M‐ficolin levels were assessed by ELISA. Results The FCN1 A/A genotype and A allele at the −144 position were more frequently observed in patients compared to the control children (43.4% vs 27.6%; odds ratio [OR]: 1.62; [95% confidence interval {CI}: 1.18‐2.2]; for the A/A genotype) and (60.8% vs 52.5%; OR: 1.4; [95% CI: 1.19‐1.65]; for the A allele); P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.24719