Synergetic Tumor Probes for Facilitating Therapeutic Delivery by Combined-Functionalized Peptide Ligands

Both targeting and penetrating ability are the key characteristics for tissue probing and precise delivery. To construct an efficient nano probing and delivery system toward human epidermal growth factor receptor 2 (HER2) positive cancer, we established a nano liposomal system functionalized with a...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2020-04, Vol.92 (8), p.5650-5655
Main Authors: Jia, Xiangqian, Guo, Mingmei, Han, Qiuju, Tian, Yuwei, Yuan, Yafei, Wang, Zihua, Qian, Yixia, Wang, Weizhi
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - therapeutic use
Cancer
Carbocyanines - chemistry
Cell Line, Tumor
Chemistry
Doxorubicin - administration & dosage
Doxorubicin - therapeutic use
Drug delivery
Drug Delivery Systems
Epidermal growth factor
ErbB-2 protein
Fluorescent Dyes - chemistry
Growth factors
HEK293 Cells
Humans
Ligands
Liposomes - chemistry
Mammary Neoplasms, Experimental - diagnostic imaging
Mammary Neoplasms, Experimental - drug therapy
Mammary Neoplasms, Experimental - metabolism
Mice
Molecular Structure
Optical Imaging
Peptides
Peptides - chemistry
Probes
Receptor, ErbB-2 - antagonists & inhibitors
Receptor, ErbB-2 - metabolism
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Summary:Both targeting and penetrating ability are the key characteristics for tissue probing and precise delivery. To construct an efficient nano probing and delivery system toward human epidermal growth factor receptor 2 (HER2) positive cancer, we established a nano liposomal system functionalized with a newly screened HER2 targeting peptide (HP2, YDLKEPEH) and the cell-penetrating peptide TAT simultaneously. Compared with the monofunctionalized liposomal probes, the dual-functional ones demonstrated a synergetic effect in cell uptake, drug delivery, and in vivo imaging. The improved efficacy of the synergetic system provides a prospective strategy for cancer diagnosis and therapy.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.0c00440