Iron Sucrose as MRI Contrast Agent in Ischemic Stroke Model

Background Despite the growing concern about the safety of gadolinium‐based contrast agents (GBCAs), they are still the most commonly used. Ferumoxytol, as an off‐label alternative MRI contrast agent, cannot be administered by a rapid bolus for dynamic susceptibility contrast perfusion‐weighted imag...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance imaging 2020-09, Vol.52 (3), p.836-849
Main Authors: Wu, Shiman, Zhang, Hua, Wang, Jing, Li, Xiaoyan, Gao, Xinyi, Fang, Ziwei, Qu, Jianxun, Wu, Yue, Ren, Yan, Rui, Wenting, Zhang, Junhai, Yao, Zhenwei
Format: Article
Language:English
Subjects:
Angiography
Animal models
Animals
Blood flow
Blood volume
Brain Ischemia - diagnostic imaging
Carotid artery
Cerebral blood flow
Cerebrovascular Circulation
contrast agent
Contrast agents
Contrast Media
Ferric Oxide, Saccharated
Field strength
Gadolinium
Head and neck
infarction
Iron
iron sucrose
Ischemia
Ischemic Stroke
Kruskal-Wallis test
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Medical imaging
middle cerebral artery
Neostriatum
Noise
Occlusion
Perfusion
Prospective Studies
Qualitative analysis
Rats
Spin labeling
Statistical analysis
Statistical tests
Stroke
Stroke - diagnostic imaging
Sucrose
Sugar
Transit time
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Despite the growing concern about the safety of gadolinium‐based contrast agents (GBCAs), they are still the most commonly used. Ferumoxytol, as an off‐label alternative MRI contrast agent, cannot be administered by a rapid bolus for dynamic susceptibility contrast perfusion‐weighted imaging (DSC‐PWI). Purpose To assess the feasibility of iron sucrose (IS) as a contrast agent for MR angiography (MRA) and DSC‐PWI. Study Type Prospective animal model. Animal Model Thirty‐six normal rats (16 for MRA, 20 for biocompability tests) and 36 occlusion of the middle cerebral artery (MCAO) model rats. Field Strength/Sequence 3.0T; head and neck angiography, using a fast spoiled gradient‐recalled‐echo (FSPGR) sequence and DSC‐MRI using echo planar imaging(EPI) sequence. Assessment MRA was performed on normal rats to examine the signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) of different doses of IS. DSC‐PWI was performed on MCAO rats at 0, 24, 48, and 72 hours postreperfusion to investigate the lesion detectability of IS. Arterial spin labeling (ASL) and DSC‐PWI enhanced by GBCAs were conducted on MCAO rats as controls. Statistical Tests Kruskal–Wallis test was used to compare qualitative assessment. One‐way analysis of variance (ANOVA) was used to compare the parametric data. Pearson's r values were evaluated between relative cerebral blood flow(rCBF)‐ASL, rCBF‐DSCIS, and rCBF obtained from DSC‐PWI enhanced by GBCA. Results The mean SNR and CNR of the common carotid artery at doses of 10 mg Fe/kg of IS were comparable with the standard dose of GBCAs (SNR: 68.04 ± 12.55 vs. 67.72 ± 14.66; CNR: 23.78 ± 7.21vs. 21.63 ± 6.83). In MCAO rat models, rCBF and relative cerebral blood volume (rCBV) of ipsilateral striatum declined (0.72 ± 0.14, 0.86 ± 0.11) with prolonged relative mean transit time (rMTT) and relative time‐to‐peak (rTTP) (1.27 ± 0.24, 1.07 ± 0.03) following occlusion. Hyperperfusion was observed in all rats at 48 and 72 hours postreperfusion, in 4/6 rats at 24 hours postreperfusion for IS‐mediated DSC‐PWI. Data Conclusion IS may be an effective contrast agent for both MRA and DSC‐PWI in ischemic stroke models. Level of Evidence 1 Technical Efficacy Stage 1 J. Magn. Reson. Imaging 2020;52:836–849.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.27109