Presence of the protein indoleamine 2,3-dioxygenase (IDO) in the maternal-fetal interface of the yolk sac placenta of blue shark, Prionace glauca

Indoleamine 2 3-dioxygenase (IDO) is a protein usually described in mammals, which, among other functions, participates in the maternal-fetal tolerance process. The blue-shark, Prionace glauca (Linnaeus, 1758) is a viviparous placentary species in which the yolk sac develops during the pregnancy, tu...

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Bibliographic Details
Published in:Fish & shellfish immunology 2020-05, Vol.100, p.256-260
Main Authors: Salmon, Thierry, Bruno, Carlos Eduardo M., de Amorim, Alberto Ferreira, Kfoury Junior, José Roberto
Format: Article
Language:English
Subjects:
Animals
Blue shark
Female
Immune system
Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis
Placenta
Pregnancy
Sharks - growth & development
Tolerance
Viviparity, Nonmammalian
Yolk Sac - enzymology
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Summary:Indoleamine 2 3-dioxygenase (IDO) is a protein usually described in mammals, which, among other functions, participates in the maternal-fetal tolerance process. The blue-shark, Prionace glauca (Linnaeus, 1758) is a viviparous placentary species in which the yolk sac develops during the pregnancy, turning into a placenta for matrotrophic nutrition of the embryo. The purpose of this study was to investigate the expression of IDO in the P. glauca maternal-fetal interface along three gestation phases and describe its distribution and the meaning of its presence. The results showed IDO labelling during the yolk sac/placenta development in the ectoderm on the three development phases and in the endoderm at the two first phases. In the uterine epithelium, IDO was observed in the last two phases. These interface tissues are major contact areas between the mother and the semiallogeneic conceptus and this relation could induce an immunological response against the fetus. Therefore, the presence of IDO may indicate that it could have a similar role in the mechanism of maternal-fetal tolerance in the P. glauca placental interface, as described in eutherian mammals. •New findings on Indoleamine 2,3-dioxygenase in relation to sharks pregnancy and developmental biochemistry:•First finding of IDO in Chondrichthyes.•IDO distribution on vertebrates.•Morphological changes in maternal fetal interface in sharks along development.
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2020.02.051