Polymeric nanoparticles for endodontic therapy

The effectiveness of novel polymeric nanoparticles (NPs) application in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment was evaluated. The effect of undoped NPs, zinc, calcium and doxycycline-doped NPs (Zn-NPs, Ca-NPs and D-NPs, respectively) was test...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the mechanical behavior of biomedical materials 2020-03, Vol.103, p.103606-103606, Article 103606
Main Authors: Toledano, Manuel, Osorio, Estrella, Aguilera, Fátima S., Muñoz-Soto, Esther, Toledano-Osorio, Manuel, López-López, Modesto T., Medina-Castillo, Antonio L., Carrasco-Carmona, Álvaro, Osorio, Raquel
Format: Article
Language:English
Subjects:
Dentin
Endodontics
Microscopy, Electron, Scanning
Mineralization
NanoDMA
Nanoparticles
Polymers
Raman
Sealing ability
Tooth Root
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effectiveness of novel polymeric nanoparticles (NPs) application in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment was evaluated. The effect of undoped NPs, zinc, calcium and doxycycline-doped NPs (Zn-NPs, Ca-NPs and D-NPs, respectively) was tested in radicular dentin. A control group without NPs was included. Radicular dentin was assessed for fluid filtration. Dentin remineralization was analyzed by scanning and transmission electron microscopy, energy-dispersive analysis, AFM, Young's modulus (Ei), Nano DMA, Raman, and X-Ray Diffraction analysis. Ca-NPs and Zn-NPs treated dentin exhibited the lowest microleakage with hermetically sealed dentinal tubules and a zinc-based salt generation onto dentin. Zn-NPs favored crystallinity and promoted the highest Ei and functional remineralization at the apical dentin, generating differences between the values of complex modulus among groups. Ca-NPs produced closure of tubules and porosities at the expense of a relative mineral amorphization, without creating zones of stress concentration. The highest sealing efficacy was obtained in Zn-NPs-treated samples, along with the highest values of Young's modulus and dentin mineralization. These high values of Ei were obtained by closing voids, cracks, pores and tubules, and by strengthening the root dentin. When using undoped NPs or Ca-NPs, deposition of minerals occurred, but radicular dentin was not mechanically reinforced. Therefore, application of Zn-NPs in endodontically treated teeth previous to the canal filling is encouraged. [Display omitted] •Radicular dentin treated with Zn-NPs showed the highest sealing ability.•Functional mineralization promoted low microleakage in root dentin with Zn-NPs.•Ca-NPs provoked precipitation of imperfect and immature minerals in root dentin.•Sealing and remineralization of dentin was not attained using doxycycline-NPs.
ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2019.103606