Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients

Hypertensive disorders of pregnancy (HDP) comprise a group of hypertension-related diseases and represent the most common medical disorders in pregnancy. The aim of this study was to investigate the risks of adverse pregnancy outcomes in patients with different types of HDP, including gestational hy...

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Bibliographic Details
Published in:Journal of human hypertension 2021-01, Vol.35 (1), p.65-73
Main Authors: Li, Xun, Zhang, Weishe, Lin, Jianhua, Liu, Huai, Yang, Zujing, Teng, Yincheng, Huang, Jingrui, Peng, Qiaozhen, Lin, Xinxiu, Zhang, Jiejie, Xie, Liangqun, Xie, Yingming, Li, Yuanqiu, Luo, Jiefeng, Duan, Weifang, Chen, Jingfei, Duan, Si
Format: Article
Language:English
Subjects:
Cohort analysis
Hypertension
Hypertension in pregnancy
Infants
Patient outcomes
Pre-eclampsia
Preeclampsia
Pregnancy
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Summary:Hypertensive disorders of pregnancy (HDP) comprise a group of hypertension-related diseases and represent the most common medical disorders in pregnancy. The aim of this study was to investigate the risks of adverse pregnancy outcomes in patients with different types of HDP, including gestational hypertension, chronic hypertension, preeclampsia (PE, early or late onset), PE superimposed on chronic hypertension (superimposed PE), eclampsia, and HELLP syndrome. Data from a multicenter retrospective patient cohort in China were analyzed. Seventeen adverse maternal or perinatal outcomes were evaluated. Logistic regression was used to estimate the risk of adverse outcomes for each HDP subgroups, using the gestational hypertension group as the reference. The final analysis included 2368 patients with HDP. Of these, 39.9% of patients reported at least one adverse pregnancy outcome. Patients with early onset PE had the highest risk for having both adverse maternal and perinatal outcomes (OR = 7.28, 95% CI: 2.68, 19.79). The risk of perinatal death significantly increased in HELLP syndrome, superimposed PE, and early onset PE, (OR = 13.81, 6.32, and 4.84, respectively, p 
ISSN:0950-9240
1476-5527
DOI:10.1038/s41371-020-0312-x