The pan-genome effector-triggered immunity landscape of a host-pathogen interaction

Effector-triggered immunity (ETI), induced by host immune receptors in response to microbial effectors, protects plants against virulent pathogens. However, a systematic study of ETI prevalence against species-wide pathogen diversity is lacking. We constructed the Type III Effector Compendium (PsyTE...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2020-02, Vol.367 (6479), p.763-768
Main Authors: Laflamme, Bradley, Dillon, Marcus M, Martel, Alexandre, Almeida, Renan N D, Desveaux, Darrell, Guttman, David S
Format: Article
Language:English
Subjects:
Alleles
Arabidopsis - genetics
Arabidopsis - immunology
Arabidopsis - microbiology
Arabidopsis Proteins - genetics
Arabidopsis Proteins - physiology
Arabidopsis thaliana
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Carrier Proteins - genetics
Carrier Proteins - physiology
Effectors
Genes
Genome, Plant
Genomes
Host plants
Host-pathogen interactions
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Immune response
Immune system
Immunity
Immunity, Innate - genetics
Microorganisms
Pathogens
Plant Diseases - genetics
Plant Diseases - immunology
Plant Diseases - microbiology
Plant Immunity - genetics
Plant protection
Proteins
Pseudomonas
Pseudomonas syringae
Pseudomonas syringae - genetics
Pseudomonas syringae - pathogenicity
Receptors
Species
Species diversity
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Summary:Effector-triggered immunity (ETI), induced by host immune receptors in response to microbial effectors, protects plants against virulent pathogens. However, a systematic study of ETI prevalence against species-wide pathogen diversity is lacking. We constructed the Type III Effector Compendium (PsyTEC) to reduce the pan-genome complexity of 5127 unique effector proteins, distributed among 70 families from 494 strains, to 529 representative alleles. We screened PsyTEC on the model plant and identified 59 ETI-eliciting alleles (11.2%) from 19 families (27.1%), with orthologs distributed among 96.8% of strains. We also identified two previously undescribed host immune receptors, including CAR1, which recognizes the conserved effectors AvrE and HopAA1, and found that 94.7% of strains harbor alleles predicted to be recognized by either CAR1 or ZAR1.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aax4079