The value of Bayesian penalized likelihood reconstruction for improving lesion conspicuity of malignant lung tumors on 18F-FDG PET/CT: comparison with ordered subset expectation maximization reconstruction incorporating time-of-flight model and point spread function correction

Objective To evaluate the value of Bayesian penalized likelihood (BPL) reconstruction for improving lesion conspicuity of malignant lung tumors on 18 F-fluoro-2-deoxy- d -glucose (FDG) positron emission tomography computed tomography (PET/CT) as compared with the ordered subset expectation maximizat...

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Bibliographic Details
Published in:Annals of nuclear medicine 2020-04, Vol.34 (4), p.272-279
Main Authors: Kurita, Yoshie, Ichikawa, Yasutaka, Nakanishi, Toshihiro, Tomita, Yoya, Hasegawa, Daisuke, Murashima, Shuichi, Hirano, Tadanori, Sakuma, Hajime
Format: Article
Language:English
Subjects:
Algorithms
Bayesian analysis
Computed tomography
Conspicuity
Diagnostic systems
Diameters
Fluorine isotopes
Glucose
Image reconstruction
Imaging
Lesions
Liver
Lung cancer
Lungs
Maximization
Medical imaging
Medicine
Medicine & Public Health
Metastases
Nuclear Medicine
Observers
Optimization
Original Article
Parenchyma
Point spread functions
Positron emission
Positron emission tomography
Radiology
Signal to noise ratio
Tomography
Tumors
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Summary:Objective To evaluate the value of Bayesian penalized likelihood (BPL) reconstruction for improving lesion conspicuity of malignant lung tumors on 18 F-fluoro-2-deoxy- d -glucose (FDG) positron emission tomography computed tomography (PET/CT) as compared with the ordered subset expectation maximization (OSEM) reconstruction incorporating time-of-flight (TOF) model and point-spread-function (PSF) correction. Methods Twenty-nine patients with primary or metastatic lung cancers who underwent 18 F-FDG PET/CT were retrospectively studied. PET images were reconstructed with OSEM + TOF, OSEM + TOF + PSF, and BPL with noise penalty strength β -value of 200, 400, 600, and 800. The signal-to-noise ratio (SNR) was determined in normal liver parenchyma. Lung lesion conspicuity was evaluated in 50 lung lesions by using a 4-point scale (0, no visible; 1, poor; 2, good; 3, excellent conspicuity). Two observers were independently asked to choose the most preferred reconstruction for detecting the lung lesions on a per-patient level. The maximum standardized uptake value (SUV max ) was measured in each of the 50 lung lesions. Results Liver SNR on the images reconstructed by BPL with β -value of 600 and 800 (17.8 ± 3.7 and 22.5 ± 4.6, respectively) was significantly higher than that by OSEM + TOF + PSF (15.0 ± 3.4, p  
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-020-01446-x