Nucleus-targeting ultrasmall ruthenium() oxide nanoparticles for photoacoustic imaging and low-temperature photothermal therapy in the NIR-II window

Nucleus-targeting NPs based on RuO 2 ( RuO 2 NPs ) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO 2 NPs with good biocompatibility and excellent photothermal properties...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (2), p.319-322
Main Authors: Liu, Zhou, Qiu, Kangqiang, Liao, Xinxing, Rees, Thomas W, Chen, Yu, Zhao, Zizhuo, Ji, Liangnian, Chao, Hui
Format: Article
Language:English
Subjects:
Biocompatibility
Cell Nucleus - drug effects
Humans
Infrared Rays
Low temperature
MCF-7 Cells
Nanoparticles
Nanoparticles - chemistry
Optical Imaging
Oxides - chemistry
Oxides - pharmacology
Particle Size
Photoacoustic Techniques
Phototherapy
Ruthenium - chemistry
Ruthenium - pharmacology
Ruthenium oxide
Surface charge
Surface Properties
Temperature
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Summary:Nucleus-targeting NPs based on RuO 2 ( RuO 2 NPs ) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO 2 NPs with good biocompatibility and excellent photothermal properties but also their unique potential for the nucleus-targeted low-temperature PTT. In the present study novel ultrasmall CS-RuO 2 NPs with intrinsic nuclear-targeting properties were developed for photoacoustic imaging and low-temperature photothermal therapy of cancer in the NIR-II window.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09728g