Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis

Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS). Methods: A total of 20 patients with r...

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Bibliographic Details
Published in:Neurological research (New York) 2020-04, Vol.42 (4), p.319-326
Main Authors: Ulusoy, Mahmut Oğuz, Horasanlı, Bahriye, Işık-Ulusoy, Selen
Format: Article
Language:English
Subjects:
Adult
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
optic neuritis
Optic Neuritis - complications
Optic Neuritis - diagnostic imaging
optical coherence tomography angiography
Tomography, Optical Coherence - methods
vessel density
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Summary:Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS). Methods: A total of 20 patients with relapsing remitting multiple sclerosis (RRMS) and 24 healthy controls were recruited in this study. All participants' superficial and deeper retinal and peripapillary layers were evaluated using OCTA after a total ophthalmologic examination. Results: In the superficial plexus, the whole image (49.53 ± 3.9% and 51.83 ± 2.1%, p = 0.009), superior hemisphere (49.44 ± 4.11% and 51.63 ± 2.3%, p = 0.018), inferior hemisphere (49.75 ± 3.9% and 52.03 ± 2.2%, p = 0.012), parafoveal (51.87 ± 3.9% and 53.08 ± 3.46%, p = 0.048) and perifoveal (50.41 ± 3.86% and 52.76 ± 2.1%, p = 0.007) vascular densities were statistically significant lesser in patients with RRMS than in controls. In the optic disc OCTA parameters, the vessel density of the inferior (50.15 ± 6.99% and 53.04 ± 3.63% p = 0.043) and temporal sector (48.09 ± 5.47% and 50.85 ± 5.24%, p = 0.045) were statistically significantly lesser in patients with RRMS than in controls. Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS.
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.2020.1726585