The Focused Ultrasound Myoma Outcome Study (FUMOS); a retrospective cohort study on long-term outcomes of MR-HIFU therapy

Objectives Since 2004, uterine fibroids have been treated with MR-HIFU, but there are persevering doubts on long-term efficacy to date. In the Focused Ultrasound Myoma Outcome Study (FUMOS), we evaluated long-term outcomes after MR-HIFU therapy, primarily to assess the reintervention rate. Methods D...

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Bibliographic Details
Published in:European radiology 2020-05, Vol.30 (5), p.2473-2482
Main Authors: Verpalen, Inez M., de Boer, Jolien P., Linstra, Marlot, Pol, Roelien L. I., Nijholt, Ingrid M., Moonen, Chrit T. W., Bartels, Lambertus W., Franx, Arie, Boomsma, Martijn F., Braat, Manon N. G.
Format: Article
Language:English
Subjects:
Ablation
Adult
Clinical Protocols
Cohort analysis
Diagnostic Radiology
Family planning
Female
Fibroids
Follow-Up Studies
High-Intensity Focused Ultrasound Ablation - methods
Humans
Imaging
Internal Medicine
Interventional
Interventional Radiology
Leiomyoma - surgery
Magnetic resonance imaging
Magnetic Resonance Imaging, Interventional - methods
Male
Medical records
Medicine
Medicine & Public Health
Middle Aged
Myoma - diagnosis
Myoma - therapy
Neuroradiology
Patients
Pregnancy
Radiology
Recovery time
Retrospective Studies
Subgroups
Surveys and Questionnaires
Therapy
Time Factors
Treatment Outcome
Ultrasonic imaging
Ultrasound
Uterine Neoplasms - diagnosis
Uterine Neoplasms - surgery
Uterine Neoplasms - therapy
Uterus
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Summary:Objectives Since 2004, uterine fibroids have been treated with MR-HIFU, but there are persevering doubts on long-term efficacy to date. In the Focused Ultrasound Myoma Outcome Study (FUMOS), we evaluated long-term outcomes after MR-HIFU therapy, primarily to assess the reintervention rate. Methods Data was retrospectively collected from 123 patients treated with MR-HIFU at our hospital from 2010 to 2017. Follow-up duration and baseline (MRI) characteristics were retrieved from medical records. Treatment failures, adverse events, and the nonperfused volume percentage (NPV%) were determined. Patients received a questionnaire about reinterventions, recovery time, satisfaction, and pregnancy outcomes. Restrictive treatment protocols were compared with unrestrictive (aiming for complete ablation) treatments. Subgroups were analyzed based on the achieved NPV
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-019-06641-7