Cell cycle regulators in cancer cell metabolism

Cancer proliferation and progression involves altered metabolic pathways as a result of continuous demand for energy and nutrients. In the last years, cell cycle regulators have been involved in the control of metabolic processes, such as glucose and insulin pathways and lipid synthesis, in addition...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular basis of disease 2020-05, Vol.1866 (5), p.165715-165715, Article 165715
Main Authors: Leal-Esteban, Lucia C., Fajas, Lluis
Format: Article
Language:English
Subjects:
Cancer
Cell cycle
Cyclin-dependent kinases
Cyclins
Metabolic adaptation
Metabolism
Mitochondria
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Summary:Cancer proliferation and progression involves altered metabolic pathways as a result of continuous demand for energy and nutrients. In the last years, cell cycle regulators have been involved in the control of metabolic processes, such as glucose and insulin pathways and lipid synthesis, in addition to their canonical function controlling cell cycle progression. Here we describe recent data demonstrating the role of cell cycle regulators in the metabolic control especially in studies performed in cancer models. Moreover, we discuss the importance of these findings in the context of current cancer therapies to provide an overview of the relevance of targeting metabolism using inhibitors of the cell cycle regulation. •Novel functions of the cell cycle regulators in metabolism are physiologically critical.•Alterations in the cell cycle regulators are associated with tumorigenesis.•These proteins control the activity of key metabolic coordinators to sustain cell survival.•Studying their role regulating energy metabolism has implications in cancer therapy.
ISSN:0925-4439
1879-260X
DOI:10.1016/j.bbadis.2020.165715