Postoperative chemotherapy improves survival in patients with resected high‐risk Stage II colorectal cancer: results of a systematic review and meta‐analysis

Aim The aim was to assess the benefit of adjuvant chemotherapy in high‐risk Stage II colorectal cancer. Method A systematic literature review and meta‐analysis was performed comparing survival in patients with resected Stage II colorectal cancer and high‐risk features having postoperative chemothera...

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Bibliographic Details
Published in:Colorectal disease 2020-10, Vol.22 (10), p.1231-1244
Main Authors: Simillis, C., Singh, H. K. S. I., Afxentiou, T., Mills, S., Warren, O. J., Smith, J. J., Riddle, P., Adamina, M., Cunningham, D., Tekkis, P. P.
Format: Article
Language:English
Subjects:
adjuvant chemotherapy
Chemotherapy
Clinical trials
Colon cancer
Colorectal cancer
Colorectal carcinoma
Literature reviews
Lymph nodes
Meta-analysis
Rectum
Stage II
Surgery
Survival
systematic review
Tumors
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Summary:Aim The aim was to assess the benefit of adjuvant chemotherapy in high‐risk Stage II colorectal cancer. Method A systematic literature review and meta‐analysis was performed comparing survival in patients with resected Stage II colorectal cancer and high‐risk features having postoperative chemotherapy vs no chemotherapy. Results Of 1031 articles screened, 29 were included, reporting on 183 749 participants. Adjuvant chemotherapy significantly improved overall survival [hazard ratio (HR) 0.61, P 
ISSN:1462-8910
1463-1318
DOI:10.1111/codi.14994